Products
ProFoldin offers products and services of drug discovery, drug delivery and biochemical assays.
SARS-CoV-2 RNA Polymerase (RdRp) Assay for Drug Discovery
The COVID-19 pandemic is caused by infection of SARS-CoV-2 or severe acute respiratory syndrome coronavirus 2, a positive-sense single-stranded RNA virus. The RNA dependent RNA polymerase (RdRp) is a key drug target for this deadly virus. The SARS-CoV-2 RdRP assay is based on detection of the RNA molecules synthesized by the RNA polymerase in the presence of an RNA template and NTPs. The assay can be performed in a 384-well or 96-well plate format for tests of the enzyme activities of the virus RNA polymerase (SARS-CoV-2 RdRp) and high throughput screening of inhibitors.
ProFoldin offers high throughput assays for validated drug targets. The assays are used for tests of inhibition or IC50 measurement of compounds against the specific drug target proteins and enzymes. The assays are in 96-well or 384-well plate format and suitable for high throughput screening (HTS). The validated drug targets include human proteins for anti-cancer and proteins from bacterial, viral and bacterial phage for anti-infection drug discovery. ProFoldin also provides enzymes, DNA, enzyme substrates and detection dyes separately for drug target protein characterization, assay optimization and HTS needs.
ProFoldin offers high throughput assays of various molecules and ions. The assays are used for concentration measurement of chemicals, drugs and ions in pharmaceutical products, environment samples, samples in scientific research projects, buffers, biochemical and chemical reactions. The assays are in 96-well format and based on fluorescence or light absorbance detection.
ProFoldin is the leading company in protein folding technology. Since 2005, ProFoldin’s protein folding columns have been widely employed to make active proteins from inclusion bodies. For membrane protein preparation, ProFoldin offers membrane protein kits for proteins expressed in inclusion bodies and membrane protein extraction kits for proteins expressed in the cell membranes.
Highly charged 96-well plates are available for DNA or protein binding. The biological molecule-bound plates can be used to study the interactions between the bound molecule and other molecules. They can be used for ELISA, studies of interactions between nucleic acids or/and proteins.
