Drug Targets, Biochemical Assays & Molecular Delivery

 

ProFoldin provides innovative protein preparation, drug target assays, drug delivery and concentration assay technologies for drug discovery and academic research.

 
   
Drug Targets and High Throughput Assays
Anticancer drug targets  Antibacterial Drug targets 
Human DNA topoisomerase I Bacterial DNA topoisomerase I
Human DNA topoisomerase II Bacterial DNA gyrases
Human PARP-1 Bacterial DNA topoisomerase IV
Human DNA polymerase alpha Bacterial DNA polymerases
Human DNA polymerase beta Bacterial RNA polymerases 
Human DNA polymerase gamma Bacterial DNA helicases
Human mitochondrial RNA polymerase Bacterial DNA primases 
Human kinases Bacterial DNA ligases    

Human mitochondrial ClpP protease

 

Bacterial kinases

M. Tuberculosis ClpP Protease

Antiviral and bacteriophage drug targets Proteases
Bacteriophage T7 RNA polymerase Bacterial cell wall synthesis (Mur) enzymes
M-MLV reverse transcriptase Bacterial D-alanine D-alanine ligases
HIV reverse transcriptase Bacterial GlmU enzymes
AMV reverse transcriptase Bacterial Isoprenoid biosynthesis (IspD) enzymes
  Bacterial PncB enzymes
DNAs, enzymes and enzyme substrates Bacterial biotin protein ligase
DNAs, enzymes and enzyme substrates Bacterial beta lactamase
   
Concentration Measurement
Biomolecules       Lipids and Detergents 
ProteinPeptide, Histidine, Cysteine lipids
DNA, ADP, UDP, GDP Detergent concentrationsDetergent CMC
Coenzyme A SDS concentrations
   
Metals         Phosphate & other chemicals
CopperZincNickel, Cobalt, Calcium, Magnesium Phosphate, Polyphosphate
  SulfateChloride
Drug molecules   EDTA, DTT 
Penicillin, Polymyxin, CisplatinOxaplatin Primary amines
   
Protein Folding, Extraction, Purification and Analysis
Protein folding columns Salt removal
Protein folding solutions Phosphate removal
Membrane protein folding  DNA removal
Membrane protein extraction Protein and DNA removal
Protein concentration Protein - protein interactions
SDS-PAGE staining Protein – DNA interactions
Protein stability and aggregation assay  
   
Molecular Delivery - Liposome Products and Liposome Research Tools
Ready-to-load liposomes for drug delivery Drug-loaded liposomes
Membrane protein reconstitution Fluorescent dyes-loaded liposomes
Liposome research tools Biomolecule or ion-loaded liposomes
   
Cell Density and Tissue Staining
Bacterial cells, insect cells Fluorescent dye for tissue staining