PROFOLDIN PROTEIN FOLDING SERVICES

Number 321

290 TURNPIKE ROAD, SUITE 6

WESTBOROUGH, MA 01581

USA

TEL: 508-845-9258

FAX: 508-845-9258

MATERIAL SAFETY DATA SHEET -PROFOLDIN PROTEIN FOLDING COLUMNS

SECTION 1. CHEMICAL IDENTIFICATION

CATALOG #: SFC01-10, SFC01, SFC02, SFC03, SFC04, SFC05, SFC06, SFC07, SFC08, SFC09, SFC10

PFC01, PFC02, PFC03, PFC04, PFC05, PFC06, PFC07, PFC08, PFC09, PFC10

NAME: ZINC CHLORIDE

SECTION 2. COMPOSITION/INFORMATION ON INGREDIENT

SUBSTANCE NAME

CAS #

SARA

ZINC CHLORIDE

7646-85-7

YES

FORMULA: ZNCL2

SYNONYMS BUTTER OF ZINC * CHLORURE DE ZINC (FRENCH) * ZINC

BUTTER * ZINC CHLORIDE FUME (ACGIH: OSHA) * ZINC

(CHLORURE DE) (FRENCH) * ZINC DICHLORIDE * ZINCO

(CLORURO DI) (ITALIAN) * ZINKCHLORID (GERMAN) *

ZINKCHLORIDE (DUTCH)

RTECS NUMBER: ZH1400000

SECTION 3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW

CORROSIVE.

HARMFUL IF SWALLOWED. CAUSES BURNS. VERY TOXIC TO AQUATIC

ORGANISMS, MAY CAUSE LONG-TERM ADVERSE EFFECTS IN THE AQUATIC

ENVIRONMENT.

HMIS RATING

HEALTH: 3

FLAMMABILITY: 0

REACTIVITY: 1

NFPA RATING

HEALTH: 3

FLAMMABILITY: 0

REACTIVITY: 1

FOR ADDITIONAL INFORMATION ON TOXICITY, PLEASE REFER TO SECTION 11.

SECTION 4. FIRST AID MEASURES

ORAL EXPOSURE

IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS

CONSCIOUS. CALL A PHYSICIAN IMMEDIATELY. DO NOT INDUCE VOMITING.

INHALATION EXPOSURE

IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE

ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.

DERMAL EXPOSURE

IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER FOR

AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES.

CALL A PHYSICIAN.

EYE EXPOSURE

IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF

WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY

SEPARATING THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

SECTION 5. FIRE FIGHTING MEASURES

FLASH POINT

N/A

AUTOIGNITION TEMP

N/A

FLAMMABILITY

N/A

FIREFIGHTING

PROTECTIVE EQUIPMENT: WEAR SELF-CONTAINED BREATHING APPARATUS

AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND EYES.

SPECIFIC HAZARD(S): EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. ACCIDENTAL RELEASE MEASURES

PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL

EVACUATE AREA.

PROCEDURE(S) OF PERSONAL PRECAUTION(S)

WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS, AND HEAVY

RUBBER GLOVES.

METHODS FOR CLEANING UP

SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. VENTILATE

AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.

SECTION 7. HANDLING AND STORAGE

HANDLING

USER EXPOSURE: DO NOT BREATHE DUST. DO NOT GET IN EYES, ON SKIN,

ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.

STORAGE

SUITABLE: KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE. HANDLE

AND STORE UNDER NITROGEN.

SPECIAL REQUIREMENTS

VERY HYGROSCOPIC.

SECTION 8. EXPOSURE CONTROLS / PPE

ENGINEERING CONTROLS

SAFETY SHOWER AND EYE BATH. USE ONLY IN A CHEMICAL FUME HOOD.

PERSONAL PROTECTIVE EQUIPMENT

RESPIRATORY: GOVERNMENT APPROVED RESPIRATOR.

HAND: COMPATIBLE CHEMICAL-RESISTANT GLOVES.

EYE: CHEMICAL SAFETY GOGGLES.

GENERAL HYGIENE MEASURES

WASH CONTAMINATED CLOTHING BEFORE REUSE. DISCARD CONTAMINATED

SHOES. WASH THOROUGHLY AFTER HANDLING.

EXPOSURE LIMITS, RTECS

COUNTRY SOURCE TYPE VALUE

USA MSHA STANDARD-AIR TWA 1 MG/M3 (FUME)

USA OSHA. PEL 8H TWA 1 MG/M3, FUME

NEW ZEALAND OEL

REMARKS: CHECK ACGIH TLV

USA NIOSH TWA 1 MG/M3

STEL 2 MG/M3

EXPOSURE LIMITS

COUNTRY SOURCE TYPE VALUE

POLAND NDS 1 MG/M3

POLAND NDSCH 2 MG/M3

POLAND NDSP -

SECTION 9. PHYSICAL/CHEMICAL PROPERTIES

APPEARANCE PHYSICAL STATE: SOLID

COLOR: WHITE

FORM: CRYSTALLINE POWDER

PROPERTY VALUE AT TEMPERATURE OR PRESSURE

MOLECULAR WEIGHT 136.28 AMU

PH N/A

BP/BP RANGE N/A

MP/MP RANGE 293 °C

FREEZING POINT N/A

VAPOR PRESSURE 1 MMHG 428 °C

VAPOR DENSITY N/A

SATURATED VAPOR CONC. N/A

SG/DENSITY 2.907 G/CM3

BULK DENSITY N/A

ODOR THRESHOLD N/A

VOLATILE% N/A

VOC CONTENT N/A

WATER CONTENT N/A

SOLVENT CONTENT N/A

EVAPORATION RATE N/A

VISCOSITY N/A

SURFACE TENSION N/A

PARTITION COEFFICIENT N/A

DECOMPOSITION TEMP. N/A

FLASH POINT N/A

EXPLOSION LIMITS N/A

FLAMMABILITY N/A

AUTOIGNITION TEMP N/A

REFRACTIVE INDEX N/A

OPTICAL ROTATION N/A

MISCELLANEOUS DATA N/A

SOLUBILITY N/A

N/A = NOT AVAILABLE

SECTION 10. STABILITY AND REACTIVITY

STABILITY

STABLE: STABLE.

CONDITIONS TO AVOID: MOISTURE.

MATERIALS TO AVOID: STRONG OXIDIZING AGENTS.

HAZARDOUS DECOMPOSITION PRODUCTS

HAZARDOUS DECOMPOSITION PRODUCTS: HYDROGEN CHLORIDE GAS, ZINC/ZINC

OXIDES, ZINC OXIDE FUMES MAY ALSO FORM.

HAZARDOUS POLYMERIZATION

HAZARDOUS POLYMERIZATION: WILL NOT OCCUR

SECTION 11. TOXICOLOGICAL INFORMATION

ROUTE OF EXPOSURE

SKIN CONTACT: CAUSES BURNS.

SKIN ABSORPTION: MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.

EYE CONTACT: CAUSES BURNS.

INHALATION: MAY BE HARMFUL IF INHALED. MATERIAL IS EXTREMELY

DESTRUCTIVE TO THE TISSUE OF THE MUCOUS MEMBRANES AND UPPER

RESPIRATORY TRACT.

INGESTION: HARMFUL IF SWALLOWED.

SIGNS AND SYMPTOMS OF EXPOSURE

INHALATION MAY RESULT IN SPASM, INFLAMMATION AND EDEMA OF THE

LARYNXAND BRONCHI, CHEMICAL PNEUMONITIS, AND PULMONARY EDEMA.

SYMPTOMS OF EXPOSURE MAY INCLUDE BURNING SENSATION, COUGHING,

WHEEZING, LARYNGITIS, SHORTNESS OF BREATH, HEADACHE, NAUSEA, AND

VOMITING. MATERIAL IS EXTREMELY DESTRUCTIVE TO TISSUE OF THE

MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT, EYES, AND SKIN. TO

THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND

TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.

TOXICITY DATA

ORAL

RAT

350 MG/KG

LD50

INTRAPERITONEAL

RAT

58 MG/KG

LD50

REMARKS: SENSE ORGANS AND SPECIAL SENSES (NOSE, EYE, EAR, AND

TASTE): EYE: MIOSIS (PUPILLIARY CONSTRICTION). VASCULAR: BP

ELEVATION NOT CHARACTERTIZED IN AUTONOMIC SECTION. NUTRITIONAL

AND GROSS METABOLIC: WEIGHT LOSS OR DECREASED WEIGHT GAIN.

INTRAVENOUS

RAT

3690 UG/KG

LD50

ORAL

MOUSE

329 MG/KG

LD50

INTRAPERITONEAL

MOUSE

24 MG/KG

LD50

SUBCUTANEOUS

MOUSE

330 MG/KG

LD50

INTRAVENOUS

MOUSE

9090 UG/KG

LD50

ORAL

GUINEA P

200 MG/KG

LD50

CHRONIC EXPOSURE - CARCINOGEN

SPECIES: HAMSTER

ROUTE OF APPLICATION: PARENTERAL

DOSE: 17 MG/KG

RESULT: TUMORIGENIC: EQUIVOCAL TUMORIGENIC AGENT BY RTECS

CRITERIA. GASTROINTESTINAL: COLON TUMORS.

SPECIES: CHICKEN

ROUTE OF APPLICATION: PARENTERAL

DOSE: 15 MG/KG

RESULT: TUMORIGENIC: EQUIVOCAL TUMORIGENIC AGENT BY RTECS

CRITERIA. TUMORIGENIC EFFECTS: TESTICULAR TUMORS.

CHRONIC EXPOSURE - TERATOGEN

SPECIES: MOUSE

DOSE: 12500 UG/KG

ROUTE OF APPLICATION: INTRAPERITONEAL

EXPOSURE TIME: (11D PREG)

RESULT: SPECIFIC DEVELOPMENTAL ABNORMALITIES: MUSCULOSKELETAL

SYSTEM.

CHRONIC EXPOSURE - MUTAGEN

SPECIES: HUMAN

DOSE: 2 MMOL/L

CELL TYPE: FIBROBLAST

MUTATION TEST: DNA DAMAGE

SPECIES: HUMAN

DOSE: 180 UMOL/L

CELL TYPE: LYMPHOCYTE

MUTATION TEST: UNSCHEDULED DNA SYNTHESIS

SPECIES: HUMAN

DOSE: 360 UMOL/L

CELL TYPE: LYMPHOCYTE

MUTATION TEST: DNA INHIBITION

SPECIES: HUMAN

DOSE: 2 MG

CELL TYPE: LYMPHOCYTE

MUTATION TEST: OTHER MUTATION TEST SYSTEMS

SPECIES: HUMAN

DOSE: 300 UMOL/L

CELL TYPE: LYMPHOCYTE

MUTATION TEST: CYTOGENETIC ANALYSIS

SPECIES: RAT

DOSE: 700 MG/KG

CELL TYPE: ASCITES TUMOR

MUTATION TEST: CYTOGENETIC ANALYSIS

SPECIES: MOUSE

ROUTE: PARENTERAL

DOSE: 16 MG/KG

MUTATION TEST: DNA INHIBITION

SPECIES: MOUSE

ROUTE: ORAL

DOSE: 18 GM/KG

EXPOSURE TIME: 30D

MUTATION TEST: CYTOGENETIC ANALYSIS

SPECIES: MOUSE

DOSE: 6 MG/KG

CELL TYPE: S. TYPHIMURIUM

MUTATION TEST: HOST-MEDIATED ASSAY

SPECIES: HAMSTER

DOSE: 180 UMOL/L

CELL TYPE: EMBRYO

MUTATION TEST: MORPHOLOGICAL TRANSFORMATION.

CHRONIC EXPOSURE - REPRODUCTIVE HAZARD

SPECIES: RAT

DOSE: 155 MG/KG

ROUTE OF APPLICATION: ORAL

EXPOSURE TIME: (33D MALE)

RESULT: PATERNAL EFFECTS: OTHER EFFECTS ON MALE.

ENDOCRINE: CHANGE IN LH. ENDOCRINE: CHANGE IN GONADOTROPINS.

SPECIES: RAT

DOSE: 6 GM/KG

ROUTE OF APPLICATION: ORAL

EXPOSURE TIME: (77D MALE/77D PRE-21D POST)

RESULT: EFFECTS ON NEWBORN: BEHAVIORAL. EFFECTS ON NEWBORN:

GROWTH STATISTICS (E.G., REDUCED WEIGHT GAIN).

SPECIES: RAT

DOSE: 30 GM/KG

ROUTE OF APPLICATION: INTRAPERITONEAL

EXPOSURE TIME: (7-8D PREG)

RESULT: EFFECTS ON FERTILITY: POST-IMPLANTATION MORTALITY (E.G.,

DEAD AND/OR RESORBED IMPLANTS PER TOTAL NUMBER OF IMPLANTS).

EFFECTS ON EMBRYO OR FETUS: FETOTOXICITY (EXCEPT DEATH, E.G.,

STUNTED FETUS). EFFECTS ON EMBRYO OR FETUS: FETAL DEATH.

SPECIES: RAT

DOSE: 37500 UG/KG

ROUTE OF APPLICATION: PARENTERAL

EXPOSURE TIME: (10D PREG)

RESULT: EFFECTS ON NEWBORN: VIABILITY INDEX (E.G., # ALIVE AT

DAY 4 PER # BORN ALIVE).

SPECIES: MOUSE

DOSE: 20500 UG/KG

ROUTE OF APPLICATION: INTRAPERITONEAL

EXPOSURE TIME: (8D PREG)

RESULT: EFFECTS ON FERTILITY: POST-IMPLANTATION MORTALITY (E.G.,

DEAD AND/OR RESORBED IMPLANTS PER TOTAL NUMBER OF IMPLANTS).

SPECIFIC DEVELOPMENTAL ABNORMALITIES: MUSCULOSKELETAL SYSTEM.

SPECIES: RABBIT

DOSE: 29184 UG/KG

ROUTE OF APPLICATION: INTRAVAGINAL

EXPOSURE TIME: (1D PRE)

RESULT: EFFECTS ON FERTILITY: FEMALE FERTILITY INDEX (E.G., #

FEMALES PREGNANT PER # SPERM POSITIVE FEMALES; # FEMALES

PREGNANT PER # FEMALES MATED ).

SECTION 12. ECOLOGICAL INFORMATION

NO DATA AVAILABLE.

SECTION 13. DISPOSAL CONSIDERATIONS

APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION

CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE

OF THIS MATERIAL. DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE

SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN

AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE, AND LOCAL

ENVIRONMENTAL REGULATIONS.

SECTION 14. TRANSPORT INFORMATION

CONTACT PROFOLDIN FOR TRANSPORTATION INFORMATION.

SECTION 15. REGULATORY INFORMATION

EU DIRECTIVES CLASSIFICATION

SYMBOL OF DANGER: C N

INDICATION OF DANGER: CORROSIVE. DANGEROUS FOR THE ENVIRONMENT.

R: 34 50/53

RISK STATEMENTS: CAUSES BURNS. VERY TOXIC TO AQUATIC ORGANISMS,

MAY CAUSE LONG-TERM ADVERSE EFFECTS IN THE AQUATIC ENVIRONMENT.

S: 7/8 28 45 60 61

SAFETY STATEMENTS: KEEP CONTAINER TIGHTLY CLOSED AND DRY. AFTER

CONTACT WITH SKIN, WASH IMMEDIATELY WITH PLENTY OF SOAP-SUDS. IN

CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE

IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE). THIS MATERIAL AND

ITS CONTAINER MUST BE DISPOSED OF AS HAZARDOUS WASTE. AVOID

RELEASE TO THE ENVIRONMENT. REFER TO SPECIAL INSTRUCTIONS/SAFETY

DATA SHEETS.

US CLASSIFICATION AND LABEL TEXT

INDICATION OF DANGER: CORROSIVE.

RISK STATEMENTS: HARMFUL IF SWALLOWED. CAUSES BURNS. VERY TOXIC

TO AQUATIC ORGANISMS, MAY CAUSE LONG-TERM ADVERSE EFFECTS IN THE

AQUATIC ENVIRONMENT.

SAFETY STATEMENTS: KEEP CONTAINER TIGHTLY CLOSED AND DRY. AFTER

CONTACT WITH SKIN, WASH IMMEDIATELY WITH PLENTY OF WATER. IN

CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE

IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE). THIS MATERIAL AND

ITS CONTAINER MUST BE DISPOSED OF AS HAZARDOUS WASTE. AVOID

RELEASE TO THE ENVIRONMENT. REFER TO SPECIAL INSTRUCTIONS/SAFETY

DATA SHEETS.

UNITED STATES REGULATORY INFORMATION

SARA LISTED: YES

DEMINIMIS: 1 %

NOTES: THIS PRODUCT IS SUBJECT TO SARA SECTION 313 REPORTING

REQUIREMENTS - ZINC COMPOUNDS.

TSCA INVENTORY ITEM: YES

CANADA REGULATORY INFORMATION

WHMIS CLASSIFICATION: THIS PRODUCT HAS BEEN CLASSIFIED IN

ACCORDANCE WITH THE HAZARD CRITERIA OF THE CPR, AND THE MSDS

CONTAINS ALL THE INFORMATION REQUIRED BY THE CPR.

DSL: YES

NDSL: NO

SECTION 16. OTHER INFORMATION

THIS PRODUCT IS FOR R&D USE ONLY. IT IS NOT FOR DRUG, HOUSEHOLD

OR OTHER USES. EMPLOYERS SHOULD USE THIS INFORMATION ONLY AS A

SUPPLEMENT TO OTHER INFORMATION GATHERED BY THEM, AND SHOULD MAKE

INDEPENDENT JUDGEMENT OF SUITABILITY OF THIS INFORMATION TO ENSURE

PROPER USE AND PROTECT THE HEALTH AND SAFETY OF EMPLOYEES. THIS

INFORMATION IS FURNISHED WITHOUT WARRANTY, AND ANY USE OF THE

PRODUCT NOT IN CONFORMANCE WITH THIS MATERIAL SAFETY DATA SHEET,

OR IN COMBINATION WITH ANY OTHER PRODUCT OR PROCESS, IS THE

RESPONSIBILITY OF THE USER. THE ABOVE INFORMATION IS BELIEVED

TO BE CORRECT BUT DOES NOT PURPORT TO BE ALL INCLUSIVE AND SHALL

BE USED ONLY AS A GUIDE. PROFOLDIN SHALL NOT BE HELD LIABLE FOR

ANY DAMAG RESULTING FROM HANDLING OR FROM CONTACT WITH THE ABOVE

PRODUCT.

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SECTION 1. CHEMICAL IDENTIFICATION

CATALOG #: SFC01-10, SFC01, SFC02, SFC03, SFC04, SFC05, SFC06, SFC07, SFC08, SFC09, SFC10

PFC01, PFC02, PFC03, PFC04, PFC05, PFC06, PFC07, PFC08, PFC09, PFC10

NAME: SODIUM ACETATE

SECTION 2. COMPOSITION/INFORMATION ON INGREDIENT

SUBSTANCE NAME

CAS #

SARA

SODIUM ACETATE TRIHYDRATE

6131-90-4

FORMULA: C2H3O2NA.3H2O

SYNONYMS SODIUM ACETATE TRIHYDRATE

RTECS NUMBER: AJ4580000

SECTION 3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW

CAUTION: AVOID CONTACT AND INHALATION.

HMIS RATING

HEALTH: 0

FLAMMABILITY: 0

REACTIVITY: 0

NFPA RATING

HEALTH: 0

FLAMMABILITY: 0

REACTIVITY: 0

FOR ADDITIONAL INFORMATION ON TOXICITY, PLEASE REFER TO SECTION 11.

SECTION 4. FIRST AID MEASURES

ORAL EXPOSURE

IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS

CONSCIOUS. CALL A PHYSICIAN.

INHALATION EXPOSURE

IF INHALED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT,

CALL A PHYSICIAN.

DERMAL EXPOSURE

IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS

AMOUNTS OF WATER.

EYE EXPOSURE

IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF

WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY

SEPARATING THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

SECTION 5. FIRE FIGHTING MEASURES

FLASH POINT

N/A

AUTOIGNITION TEMP

600 °C

FLAMMABILITY

N/A

EXTINGUISHING MEDIA

SUITABLE: WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER, OR

APPROPRIATE FOAM.

FIREFIGHTING

PROTECTIVE EQUIPMENT: WEAR SELF-CONTAINED BREATHING APPARATUS

AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND EYES.

SPECIFIC HAZARD(S): EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. ACCIDENTAL RELEASE MEASURES

PROCEDURE(S) OF PERSONAL PRECAUTION(S)

EXERCISE APPROPRIATE PRECAUTIONS TO MINIMIZE DIRECT CONTACT WITH

SKIN OR EYES AND PREVENT INHALATION OF DUST.

METHODS FOR CLEANING UP

SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID

RAISING DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL

PICKUP IS COMPLETE.

SECTION 7. HANDLING AND STORAGE

HANDLING

USER EXPOSURE: AVOID INHALATION. AVOID CONTACT WITH EYES, SKIN,

AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.

STORAGE

SUITABLE: KEEP TIGHTLY CLOSED.

SECTION 8. EXPOSURE CONTROLS / PPE

ENGINEERING CONTROLS

SAFETY SHOWER AND EYE BATH. MECHANICAL EXHAUST REQUIRED.

PERSONAL PROTECTIVE EQUIPMENT

RESPIRATORY: WEAR DUST MASK.

HAND: PROTECTIVE GLOVES.

EYE: CHEMICAL SAFETY GOGGLES.

GENERAL HYGIENE MEASURES

WASH THOROUGHLY AFTER HANDLING.

SECTION 9. PHYSICAL/CHEMICAL PROPERTIES

APPEARANCE PHYSICAL STATE: SOLID

COLOR: WHITE

FORM: FINE CRYSTALS

PROPERTY VALUE AT TEMPERATURE OR PRESSURE

MOLECULAR WEIGHT 136.08 AMU

PH 8.5 - 1

BP/BP RANGE N/A

MP/MP RANGE N/A

FREEZING POINT N/A

VAPOR PRESSURE N/A

VAPOR DENSITY N/A

SATURATED VAPOR CONC. N/A

SG/DENSITY N/A

BULK DENSITY 800 KG/L

ODOR THRESHOLD N/A

VOLATILE% N/A

VOC CONTENT N/A

WATER CONTENT N/A

SOLVENT CONTENT N/A

EVAPORATION RATE N/A

VISCOSITY N/A

SURFACE TENSION N/A

PARTITION COEFFICIENT N/A

DECOMPOSITION TEMP. N/A

FLASH POINT N/A

EXPLOSION LIMITS N/A

FLAMMABILITY N/A

AUTOIGNITION TEMP 600 °C

REFRACTIVE INDEX N/A

OPTICAL ROTATION N/A

MISCELLANEOUS DATA N/A

SOLUBILITY SOLUBILITY IN WATER: 3 M IN H2O, 20°C

COMPLETE, COLORLESS

N/A = NOT AVAILABLE

SECTION 10. STABILITY AND REACTIVITY

STABILITY

STABLE: STABLE.

MATERIALS TO AVOID: STRONG OXIDIZING AGENTS.

HAZARDOUS DECOMPOSITION PRODUCTS

HAZARDOUS DECOMPOSITION PRODUCTS: CARBON MONOXIDE, CARBON DIOXIDE,

SODIUM/SODIUM OXIDES.

HAZARDOUS POLYMERIZATION

HAZARDOUS POLYMERIZATION: WILL NOT OCCUR

SECTION 11. TOXICOLOGICAL INFORMATION

ROUTE OF EXPOSURE

SKIN CONTACT: MAY CAUSE SKIN IRRITATION.

SKIN ABSORPTION: MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.

EYE CONTACT: MAY CAUSE EYE IRRITATION.

INHALATION: MAY BE HARMFUL IF INHALED. MATERIAL MAY BE

IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT.

INGESTION: MAY BE HARMFUL IF SWALLOWED.

SIGNS AND SYMPTOMS OF EXPOSURE

TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND

TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.

CHRONIC EXPOSURE - MUTAGEN

SPECIES: RAT

ROUTE: ORAL

DOSE: 11 MMOL/KG

MUTATION TEST: UNSCHEDULED DNA SYNTHESIS

SECTION 12. ECOLOGICAL INFORMATION

NO DATA AVAILABLE.

SECTION 13. DISPOSAL CONSIDERATIONS

APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION

CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE

OF THIS MATERIAL. DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE

SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN

AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE, AND LOCAL

ENVIRONMENTAL REGULATIONS.

SECTION 14. TRANSPORT INFORMATION

CONTACT PROFOLDIN FOR TRANSPORTATION INFORMATION.

SECTION 15. REGULATORY INFORMATION

US CLASSIFICATION AND LABEL TEXT

US STATEMENTS: CAUTION: AVOID CONTACT AND INHALATION.

UNITED STATES REGULATORY INFORMATION

SARA LISTED: NO

CANADA REGULATORY INFORMATION

WHMIS CLASSIFICATION: THIS PRODUCT HAS BEEN CLASSIFIED IN

ACCORDANCE WITH THE HAZARD CRITERIA OF THE CPR, AND THE MSDS

CONTAINS ALL THE INFORMATION REQUIRED BY THE CPR.

DSL: NO

NDSL: NO

SECTION 16. OTHER INFORMATION

THIS PRODUCT IS FOR R&D USE ONLY. IT IS NOT FOR DRUG, HOUSEHOLD

OR OTHER USES. EMPLOYERS SHOULD USE THIS INFORMATION ONLY AS A

SUPPLEMENT TO OTHER INFORMATION GATHERED BY THEM, AND SHOULD MAKE

INDEPENDENT JUDGEMENT OF SUITABILITY OF THIS INFORMATION TO ENSURE

PROPER USE AND PROTECT THE HEALTH AND SAFETY OF EMPLOYEES. THIS

INFORMATION IS FURNISHED WITHOUT WARRANTY, AND ANY USE OF THE

PRODUCT NOT IN CONFORMANCE WITH THIS MATERIAL SAFETY DATA SHEET,

OR IN COMBINATION WITH ANY OTHER PRODUCT OR PROCESS, IS THE

RESPONSIBILITY OF THE USER. THE ABOVE INFORMATION IS BELIEVED

TO BE CORRECT BUT DOES NOT PURPORT TO BE ALL INCLUSIVE AND SHALL

BE USED ONLY AS A GUIDE. PROFOLDIN SHALL NOT BE HELD LIABLE FOR

ANY DAMAG RESULTING FROM HANDLING OR FROM CONTACT WITH THE ABOVE

PRODUCT.

SECTION 1. CHEMICAL IDENTIFICATION

CATALOG #: SFC01-10, SFC01, SFC02, SFC03, SFC04, SFC05, SFC06, SFC07, SFC08, SFC09, SFC10

PFC01, PFC02, PFC03, PFC04, PFC05, PFC06, PFC07, PFC08, PFC09, PFC10

NAME: SODIUM AZIDE

SECTION 2. COMPOSITION/INFORMATION ON INGREDIENT

SUBSTANCE NAME

CAS #

SARA

SODIUM AZIDE

26628-22-8

YES

FORMULA: NAN3

SYNONYMS AZIDE, SODIUM * AZOTURE DE SODIUM (FRENCH) *

AZYDEK SODU (POLISH) * KAZOE * NATRIUMAZID

(GERMAN) * NATRIUMMAZIDE (DUTCH) * NCI-C06462 *

NEMAZYD * NSC 3072 * RCRA WASTE NUMBER P105 *

SMITE * SODIUM AZIDE (ACGIH) * SODIUM, AZOTURE DE

(FRENCH) * SODIUM, AZOTURO DI (ITALIAN) * U-3886

RTECS NUMBER: VY8050000

SECTION 3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW

HIGHLY TOXIC (USA) VERY TOXIC (EU).

HEATING MAY CAUSE AN EXPLOSION. VERY TOXIC BY INHALATION, IN

CONTACT WITH SKIN AND IF SWALLOWED. CONTACT WITH ACIDS LIBERATES

VERY TOXIC GAS. VERY TOXIC TO AQUATIC ORGANISMS, MAY CAUSE

LONG-TERM ADVERSE EFFECTS IN THE AQUATIC ENVIRONMENT.

READILY ABSORBED THROUGH SKIN. SODIUM AZIDE MAY REACT WITH LEAD

AND COPPER PLUMBING TO FORM HIGHLY EXPLOSIVE METAL AZIDES. TARGET

ORGAN(S): NERVES. HEART.

HMIS RATING

HEALTH: 4*

FLAMMABILITY: 0

REACTIVITY: 2

NFPA RATING

HEALTH: 4

FLAMMABILITY: 0

REACTIVITY: 2

*ADDITIONAL CHRONIC HAZARDS PRESENT.

FOR ADDITIONAL INFORMATION ON TOXICITY, PLEASE REFER TO SECTION 11.

SECTION 4. FIRST AID MEASURES

ORAL EXPOSURE

IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS

CONSCIOUS. CALL A PHYSICIAN IMMEDIATELY.

INHALATION EXPOSURE

IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE

ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.

DERMAL EXPOSURE

IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER FOR

AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES.

CALL A PHYSICIAN.

EYE EXPOSURE

IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF

WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY

SEPARATING THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

SECTION 5. FIRE FIGHTING MEASURES

EXPLOSION HAZARDS

CONTAINER EXPLOSION MAY OCCUR UNDER FIRE CONDITIONS. AZIDE

REACTS WITH MANY HEAVY METALS SUCH AS LEAD, COPPER, MERCURY,

SILVER, GOLD TO FORM EXPLOSIVE COMPOUNDS. COPPER AND LEAD AZIDES

ARE MORE SENSITIVE THAN NITROGLYCERINE. AZIDE REACTS WITH METAL

HALIDES TO GIVE A RANGE OF METAL AZIDE HALIDES, MANY OF WHICH

ARE EXPLOSIVE. INCOMPATIBLE WITH CHROMYL CHLORIDE, HYDRAZINE,

BROMINE, CARBON DISULFIDE, DIMETHYL SULFATE, DIBROMOMALONITRILE.

AN EXPLOSION OCCURRED WHEN A MIXTURE OF SODIUM AZIDE, METHYLENE

CHLORIDE, DIMETHYL SULFOXIDE, AND SULFURIC ACID WERE BEING

CONCENTRATED ON A ROTARY EVAPORATOR.

FLASH POINT

N/A

AUTOIGNITION TEMP

N/A

FLAMMABILITY

N/A

EXTINGUISHING MEDIA

SUITABLE: DRY CHEMICAL POWDER.

UNSUITABLE: DO NOT USE WATER.

FIREFIGHTING

PROTECTIVE EQUIPMENT: WEAR SELF-CONTAINED BREATHING APPARATUS

AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND EYES.

SPECIFIC HAZARD(S): EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. ACCIDENTAL RELEASE MEASURES

PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL

EVACUATE AREA.

PROCEDURE(S) OF PERSONAL PRECAUTION(S)

WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS, AND HEAVY

RUBBER GLOVES.

METHODS FOR CLEANING UP

SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID

RAISING DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL

PICKUP IS COMPLETE.

SECTION 7. HANDLING AND STORAGE

HANDLING

USER EXPOSURE: DO NOT BREATHE DUST. DO NOT GET IN EYES, ON SKIN,

ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.

STORAGE

SUITABLE: KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE.

INCOMPATIBLE MATERIALS: AZIDE REACTS WITH MANY HEAVY METALS SUCH

AS LEAD, COPPER, MERCURY, SILVER, GOLD TO FORM EXPLOSIVE

COMPOUNDS. COPPER AND LEAD AZIDES ARE MORE SENSITIVE THAN

NITROGLYCERINE. AZIDE REACTS WITH METAL HALIDES TO GIVE A RANGE

OF METAL AZIDE HALIDES, MANY OF WHICH ARE EXPLOSIVE.

INCOMPATIBLE WITH CHROMYL CHLORIDE, HYDRAZINE, BROMINE, CARBON

DISULFIDE, DIMETHYL SULFATE, DIBROMOMALONITRILE.

SPECIAL REQUIREMENTS

HEAT SENSITIVE.

SECTION 8. EXPOSURE CONTROLS / PPE

ENGINEERING CONTROLS

SAFETY SHOWER AND EYE BATH. USE ONLY IN A CHEMICAL FUME HOOD.

PERSONAL PROTECTIVE EQUIPMENT

RESPIRATORY: GOVERNMENT APPROVED RESPIRATOR.

HAND: COMPATIBLE CHEMICAL-RESISTANT GLOVES.

EYE: CHEMICAL SAFETY GOGGLES.

GENERAL HYGIENE MEASURES

WASH CONTAMINATED CLOTHING BEFORE REUSE. WASH THOROUGHLY AFTER

HANDLING.

EXPOSURE LIMITS, RTECS

COUNTRY SOURCE TYPE VALUE

USA ACGIH CEILING CO0.29 MG/M3 (SODIUM AZIDE)

NEW ZEALAND OEL

REMARKS: CHECK ACGIH TLV

USA NIOSH CEILING CO0.1 PPM (SK)

EXPOSURE LIMITS

COUNTRY SOURCE TYPE VALUE

POLAND NDS 0.1 MG/M3

POLAND NDSCH 0.3 MG/M3

POLAND NDSP

SECTION 9. PHYSICAL/CHEMICAL PROPERTIES

APPEARANCE PHYSICAL STATE: SOLID

COLOR: WHITE

FORM: FINE CRYSTALS

PROPERTY VALUE AT TEMPERATURE OR PRESSURE

MOLECULAR WEIGHT 65.01 AMU

PH 10

BP/BP RANGE N/A

MP/MP RANGE 275 °C

FREEZING POINT N/A

VAPOR PRESSURE N/A

VAPOR DENSITY N/A

SATURATED VAPOR CONC. N/A

SG/DENSITY 1.85 G/CM3

BULK DENSITY N/A

ODOR THRESHOLD N/A

VOLATILE% N/A

VOC CONTENT N/A

WATER CONTENT N/A

SOLVENT CONTENT N/A

EVAPORATION RATE N/A

VISCOSITY N/A

SURFACE TENSION N/A

PARTITION COEFFICIENT N/A

DECOMPOSITION TEMP. N/A

FLASH POINT N/A

EXPLOSION LIMITS N/A

FLAMMABILITY N/A

AUTOIGNITION TEMP N/A

REFRACTIVE INDEX N/A

OPTICAL ROTATION N/A

MISCELLANEOUS DATA N/A

SOLUBILITY SOLUBILITY IN WATER: 1 M IN H2O, 20°C

COMPLETE, COLORLESS

N/A = NOT AVAILABLE

SECTION 10. STABILITY AND REACTIVITY

STABILITY

STABLE: STABLE.

CONDITIONS OF INSTABILITY: HEAT SENSITIVE.

CONDITIONS TO AVOID: EXPLODES WHEN HEATED.

MATERIALS TO AVOID: HALOGENATED SOLVENTS AVOID CONTACT WITH

METALS. AVOID CONTACT WITH ACID., ACID CHLORIDES

HAZARDOUS DECOMPOSITION PRODUCTS

HAZARDOUS DECOMPOSITION PRODUCTS: NITROGEN OXIDES REACTS WITH

PROTIC SOLVENTS (WATER, ALCOHOLS, AMINES, ETC.) TO RELEASE TOXIC

HYDRAZOIC ACID

HAZARDOUS DECOMPOSITION PRODUCTS FORMED UPON CONTACT WITH WATER:

REACTS WITH PROTIC SOLVENTS (WATER, ALCOHOLS, AMINES, ETC.) TO

RELEASE TOXIC HYDRAZOIC ACID

HAZARDOUS POLYMERIZATION

HAZARDOUS POLYMERIZATION: WILL NOT OCCUR

SECTION 11. TOXICOLOGICAL INFORMATION

ROUTE OF EXPOSURE

SKIN CONTACT: MAY CAUSE SKIN IRRITATION.

SKIN ABSORPTION: MAY BE FATAL IF ABSORBED THROUGH SKIN.

EYE CONTACT: MAY CAUSE EYE IRRITATION.

INHALATION: MAY BE FATAL IF INHALED. MATERIAL MAY BE IRRITATING

TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT.

INGESTION: MAY BE FATAL IF SWALLOWED.

TARGET ORGAN(S) OR SYSTEM(S)

NERVES. HEART. BRAIN.

SIGNS AND SYMPTOMS OF EXPOSURE

EXPOSURE CAN CAUSE: NAUSEA, HEADACHE, AND VOMITING. LABORATORY

EXPERIMENTS IN ANIMALS HAVE SHOWN SODIUM AZIDE TO PRODUCE A

PROFOUND HYPOTENSIVE EFFECT, DEMYELINATION OF MYELINATED NERVE

FIBERS IN THE CENTRAL NERVOUS SYSTEM, TESTICULAR DAMAGE,

BLINDNESS, ATTACKS OF RIGIDITY, AND HEPATIC AND CEREBRAL EFFECTS.

TOXICITY DATA

ORAL

WOMAN

786 MG/KG

LDLO

REMARKS: BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD.

BEHAVIORAL: COMA. CARDIAC: ARRYTHMIAS (INCLUDING CHANGES IT

CONDUCTION).

ORAL

MAN

29 MG/KG

LDLO

REMARKS: BRAIN AND COVERINGS: INCREASED INTRACRANIAL PRESSURE.

CARDIAC: PULSE RATE. LUNGS, THORAX, OR RESPIRATION: ACUTE

PULMONARY EDEMA.

ORAL

MAN

129 MG/KG

LDLO

REMARKS: BEHAVIORAL: COMA. CARDIAC: PULSE RATE. CARDIAC: OTHER

CHANGES.

ORAL

WOMAN

14 MG/KG

LDLO

REMARKS: BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD.

CARDIAC: ARRYTHMIAS (INCLUDING CHANGES IT CONDUCTION).

CARDIAC: CHANGE IN FORCE OF CONTRACTION.

ORAL

MAN

143 MG/KG

LDLO

REMARKS: SENSE ORGANS AND SPECIAL SENSES (NOSE, EYE, EAR, AND

TASTE): EYE: MYDRIASIS (PUPILLIARY DILATION).

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY).

BEHAVIORAL: IRRITABILITY.

ORAL

RAT

27 MG/KG

LD50

INHALATION

RAT

37 MG/M3

LC50

REMARKS: SENSE ORGANS AND SPECIAL SENSES (NOSE, EYE, EAR, AND

TASTE): EYE: OTHER. BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE

THRESHOLD. LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR

FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI.

SKIN

RAT

50 MG/KG

LD50

SUBCUTANEOUS

RAT

45100 UG/KG

LD50

REMARKS: PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH

OR WITHOUT SENSORY CHANGE. LUNGS, THORAX, OR RESPIRATION: OTHER

CHANGES.

INTRATRACHEAL

RAT

47500 UG/KG

LD50

REMARKS: PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH

OR WITHOUT SENSORY CHANGE. LUNGS, THORAX, OR RESPIRATION: OTHER

CHANGES.

ORAL

MOUSE

27 MG/KG

LD50

INHALATION

MOUSE

32.4 MG/M3

LC50

REMARKS: SENSE ORGANS AND SPECIAL SENSES (NOSE, EYE, EAR, AND

TASTE): EYE: OTHER. BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE

THRESHOLD. LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR

FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI.

INTRAPERITONEAL

MOUSE

28 MG/KG

LD50

REMARKS: BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD.

BEHAVIORAL: CHANGE IN MOTOR ACTIVITY (SPECIFIC ASSAY). LUNGS,

THORAX, OR RESPIRATION: RESPIRATORY STIMULATION.

SUBCUTANEOUS

MOUSE

23060 UG/KG

LD50

REMARKS: PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH

OR WITHOUT SENSORY CHANGE. LUNGS, THORAX, OR RESPIRATION: OTHER

CHANGES.

INTRAVENOUS

MOUSE

19 MG/KG

LD50

SKIN

RABBIT

20 MG/KG

LD50

ORAL

BIRD (WILD)

23.7 MG/KG

LD50

CHRONIC EXPOSURE - CARCINOGEN

SPECIES: RAT

ROUTE OF APPLICATION: ORAL

DOSE: 2730 MG/KG

EXPOSURE TIME: 78W

FREQUENCY: C

RESULT: TUMORIGENIC: EQUIVOCAL TUMORIGENIC AGENT BY RTECS

CRITERIA. ENDOCRINE: TUMORS. SKIN AND APPENDAGES: OTHER: TUMORS.

SPECIES: RAT

ROUTE OF APPLICATION: ORAL

DOSE: 5460 MG/KG

EXPOSURE TIME: 78W

FREQUENCY: C

RESULT: TUMORIGENIC: EQUIVOCAL TUMORIGENIC AGENT BY RTECS

CRITERIA. ENDOCRINE: TUMORS. SKIN AND APPENDAGES: OTHER: TUMORS.

NTP CARCINOGEN LIST

RATING: NO EVIDENCE.

SPECIES: RAT

ROUTE: GAVAGE

ACGIH CARCINOGEN LIST

RATING: A4

CHRONIC EXPOSURE - MUTAGEN

RESULT: LABORATORY EXPERIMENTS HAVE SHOWN MUTAGENIC EFFECTS.

SPECIES: OTHER INSECTS

ROUTE: ORAL

DOSE: 100 MG/L

MUTATION TEST: HERITABLE TRANSLOCATION TEST

SPECIES: HUMAN

DOSE: 30 MMOL/L

CELL TYPE: HELA CELL

MUTATION TEST: DNA INHIBITION

SPECIES: HUMAN

DOSE: 50 MG/L

CELL TYPE: FIBROBLAST

MUTATION TEST: DNA INHIBITION

SPECIES: RAT

DOSE: 1 MMOL/L

CELL TYPE: LIVER

MUTATION TEST: MUTATION IN MAMMALIAN SOMATIC CELLS.

SPECIES: MOUSE

DOSE: 500 MG/L

EXPOSURE TIME: 2H

CELL TYPE: LYMPHOCYTE

MUTATION TEST: MUTATION IN MAMMALIAN SOMATIC CELLS.

SPECIES: HAMSTER

DOSE: 1 MMOL/L

CELL TYPE: LUNG

MUTATION TEST: MUTATION IN MAMMALIAN SOMATIC CELLS.

SECTION 12. ECOLOGICAL INFORMATION

ACUTE ECOTOXICITY TESTS

TEST TYPE: EC50 DAPHNIA

SPECIES: DAPHNIA PULEX

TIME: 48 H

VALUE: 4.2 MG/L

TEST TYPE: LC50 FISH

SPECIES: PIMEPHALES PROMELAS (FATHEAD MINNOW)

TIME: 96 H

VALUE: 5.46 MG/L

TEST TYPE: LC50 FISH

SPECIES: ONCHORHYNCHUS MYKISS (RAINBOW TROUT)

TIME: 96 H

VALUE: 3.92 MG/L

SECTION 13. DISPOSAL CONSIDERATIONS

APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION

CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE

OF THIS MATERIAL. OBSERVE ALL FEDERAL, STATE, AND LOCAL

ENVIRONMENTAL REGULATIONS.

SECTION 14. TRANSPORT INFORMATION

CONTACT PROFOLDIN FOR TRANSPORTATION INFORMATION.

SECTION 15. REGULATORY INFORMATION

EU DIRECTIVES CLASSIFICATION

SYMBOL OF DANGER: T+ N

INDICATION OF DANGER: VERY TOXIC. DANGEROUS FOR THE ENVIRONMENT.

R: 28 32 50/53

RISK STATEMENTS: VERY TOXIC IF SWALLOWED. CONTACT WITH ACIDS

LIBERATES VERY TOXIC GAS. VERY TOXIC TO AQUATIC ORGANISMS, MAY

CAUSE LONG-TERM ADVERSE EFFECTS IN THE AQUATIC ENVIRONMENT.

S: 28 45 60 61

SAFETY STATEMENTS: AFTER CONTACT WITH SKIN, WASH IMMEDIATELY

WITH PLENTY OF SOAP-SUDS. IN CASE OF ACCIDENT OR IF YOU FEEL

UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY (SHOW THE LABEL WHERE

POSSIBLE). THIS MATERIAL AND ITS CONTAINER MUST BE DISPOSED OF

AS HAZARDOUS WASTE. AVOID RELEASE TO THE ENVIRONMENT. REFER TO

SPECIAL INSTRUCTIONS/SAFETY DATA SHEETS.

US CLASSIFICATION AND LABEL TEXT

INDICATION OF DANGER: HIGHLY TOXIC (USA) VERY TOXIC (EU).

RISK STATEMENTS: HEATING MAY CAUSE AN EXPLOSION. VERY TOXIC BY

INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED. CONTACT WITH

ACIDS LIBERATES VERY TOXIC GAS. VERY TOXIC TO AQUATIC ORGANISMS,

MAY CAUSE LONG-TERM ADVERSE EFFECTS IN THE AQUATIC ENVIRONMENT.

SAFETY STATEMENTS: IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL,

SEEK MEDICAL ADVICE IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).

WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES, AND EYE/FACE

PROTECTION. DO NOT BREATHE DUST.

US STATEMENTS: READILY ABSORBED THROUGH SKIN. SODIUM AZIDE MAY

REACT WITH LEAD AND COPPER PLUMBING TO FORM HIGHLY EXPLOSIVE

METAL AZIDES. TARGET ORGAN(S): NERVES. HEART.

UNITED STATES REGULATORY INFORMATION

SARA LISTED: YES

DEMINIMIS: 1 %

NOTES: THIS PRODUCT IS SUBJECT TO SARA SECTION 313 REPORTING

REQUIREMENTS.

TSCA INVENTORY ITEM: YES

CANADA REGULATORY INFORMATION

WHMIS CLASSIFICATION: THIS PRODUCT HAS BEEN CLASSIFIED IN

ACCORDANCE WITH THE HAZARD CRITERIA OF THE CPR, AND THE MSDS

CONTAINS ALL THE INFORMATION REQUIRED BY THE CPR.

DSL: YES

NDSL: NO

SECTION 16. OTHER INFORMATION

THIS PRODUCT IS FOR R&D USE ONLY. IT IS NOT FOR DRUG, HOUSEHOLD

OR OTHER USES. EMPLOYERS SHOULD USE THIS INFORMATION ONLY AS A

SUPPLEMENT TO OTHER INFORMATION GATHERED BY THEM, AND SHOULD MAKE

INDEPENDENT JUDGEMENT OF SUITABILITY OF THIS INFORMATION TO ENSURE

PROPER USE AND PROTECT THE HEALTH AND SAFETY OF EMPLOYEES. THIS

INFORMATION IS FURNISHED WITHOUT WARRANTY, AND ANY USE OF THE

PRODUCT NOT IN CONFORMANCE WITH THIS MATERIAL SAFETY DATA SHEET,

OR IN COMBINATION WITH ANY OTHER PRODUCT OR PROCESS, IS THE

RESPONSIBILITY OF THE USER. THE ABOVE INFORMATION IS BELIEVED

TO BE CORRECT BUT DOES NOT PURPORT TO BE ALL INCLUSIVE AND SHALL

BE USED ONLY AS A GUIDE. PROFOLDIN SHALL NOT BE HELD LIABLE FOR

ANY DAMAG RESULTING FROM HANDLING OR FROM CONTACT WITH THE ABOVE

PRODUCT.

SECTION 1. CHEMICAL IDENTIFICATION

CATALOG #: SFC01-10, SFC01, SFC02, SFC03, SFC04, SFC05, SFC06, SFC07, SFC08, SFC09, SFC10

PFC01, PFC02, PFC03, PFC04, PFC05, PFC06, PFC07, PFC08, PFC09, PFC10

NAME: MAGNESIUM ACETATE

SECTION 2. COMPOSITION/INFORMATION ON INGREDIENT

SUBSTANCE NAME

CAS #

SARA

MAGNESIUM ACETATE TETRAHYDRATE

16674-78-5

FORMULA: (C2H3O2)2MG.4H2O

SECTION 3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW

CAUTION: AVOID CONTACT AND INHALATION. TARGET ORGAN(S): CENTRAL

NERVOUS SYSTEM. G.I. SYSTEM.

HMIS RATING

HEALTH: 1*

FLAMMABILITY: 0

REACTIVITY: 1

NFPA RATING

HEALTH: 1

FLAMMABILITY: 0

REACTIVITY: 1

*ADDITIONAL CHRONIC HAZARDS PRESENT.

FOR ADDITIONAL INFORMATION ON TOXICITY, PLEASE REFER TO SECTION 11.

SECTION 4. FIRST AID MEASURES

ORAL EXPOSURE

IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS

CONSCIOUS. CALL A PHYSICIAN.

INHALATION EXPOSURE

IF INHALED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT,

CALL A PHYSICIAN.

DERMAL EXPOSURE

IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS

AMOUNTS OF WATER.

EYE EXPOSURE

IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF

WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY

SEPARATING THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

SECTION 5. FIRE FIGHTING MEASURES

FLASH POINT

N/A

AUTOIGNITION TEMP

N/A

FLAMMABILITY

N/A

EXTINGUISHING MEDIA

SUITABLE: WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER, OR

APPROPRIATE FOAM.

FIREFIGHTING

PROTECTIVE EQUIPMENT: WEAR SELF-CONTAINED BREATHING APPARATUS

AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND EYES.

SPECIFIC HAZARD(S): EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. ACCIDENTAL RELEASE MEASURES

PROCEDURE(S) OF PERSONAL PRECAUTION(S)

EXERCISE APPROPRIATE PRECAUTIONS TO MINIMIZE DIRECT CONTACT WITH

SKIN OR EYES AND PREVENT INHALATION OF DUST.

METHODS FOR CLEANING UP

SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID

RAISING DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL

PICKUP IS COMPLETE.

SECTION 7. HANDLING AND STORAGE

HANDLING

USER EXPOSURE: AVOID INHALATION. AVOID CONTACT WITH EYES, SKIN,

AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.

STORAGE

SUITABLE: KEEP TIGHTLY CLOSED.

SPECIAL REQUIREMENTS

MOISTURE SENSITIVE.

SECTION 8. EXPOSURE CONTROLS / PPE

ENGINEERING CONTROLS

SAFETY SHOWER AND EYE BATH. MECHANICAL EXHAUST REQUIRED.

PERSONAL PROTECTIVE EQUIPMENT

RESPIRATORY: WEAR DUST MASK.

HAND: PROTECTIVE GLOVES.

EYE: CHEMICAL SAFETY GOGGLES.

GENERAL HYGIENE MEASURES

WASH THOROUGHLY AFTER HANDLING.

SECTION 9. PHYSICAL/CHEMICAL PROPERTIES

APPEARANCE PHYSICAL STATE: SOLID

COLOR: WHITE

FORM: FINE CRYSTALS

PROPERTY VALUE AT TEMPERATURE OR PRESSURE

MOLECULAR WEIGHT 214.46 AMU

PH N/A

BP/BP RANGE N/A

MP/MP RANGE 80 °C

FREEZING POINT N/A

VAPOR PRESSURE N/A

VAPOR DENSITY N/A

SATURATED VAPOR CONC. N/A

SG/DENSITY 1.454 G/CM3

BULK DENSITY N/A

ODOR THRESHOLD N/A

VOLATILE% N/A

VOC CONTENT N/A

WATER CONTENT N/A

SOLVENT CONTENT N/A

EVAPORATION RATE N/A

VISCOSITY N/A

SURFACE TENSION N/A

PARTITION COEFFICIENT N/A

DECOMPOSITION TEMP. N/A

FLASH POINT N/A

EXPLOSION LIMITS N/A

FLAMMABILITY N/A

AUTOIGNITION TEMP N/A

REFRACTIVE INDEX N/A

OPTICAL ROTATION N/A

MISCELLANEOUS DATA N/A

SOLUBILITY N/A

N/A = NOT AVAILABLE

SECTION 10. STABILITY AND REACTIVITY

STABILITY

STABLE: STABLE.

CONDITIONS TO AVOID: MOISTURE.

MATERIALS TO AVOID: STRONG OXIDIZING AGENTS.

HAZARDOUS DECOMPOSITION PRODUCTS

HAZARDOUS DECOMPOSITION PRODUCTS: CARBON MONOXIDE, CARBON DIOXIDE,

MAGNESIUM OXIDE.

HAZARDOUS POLYMERIZATION

HAZARDOUS POLYMERIZATION: WILL NOT OCCUR

SECTION 11. TOXICOLOGICAL INFORMATION

ROUTE OF EXPOSURE

SKIN CONTACT: MAY CAUSE SKIN IRRITATION.

SKIN ABSORPTION: MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.

EYE CONTACT: MAY CAUSE EYE IRRITATION.

INHALATION: MAY BE HARMFUL IF INHALED. MATERIAL MAY BE

IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT.

INGESTION: MAY BE HARMFUL IF SWALLOWED.

TARGET ORGAN(S) OR SYSTEM(S)

CENTRAL NERVOUS SYSTEM. G.I. SYSTEM.

SIGNS AND SYMPTOMS OF EXPOSURE

TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND

TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.

TOXICITY DATA

INTRAVENOUS

MOUSE

111 MG/KG

LD50

SECTION 12. ECOLOGICAL INFORMATION

NO DATA AVAILABLE.

SECTION 13. DISPOSAL CONSIDERATIONS

APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION

CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE

OF THIS MATERIAL. DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE

SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN

AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE, AND LOCAL

ENVIRONMENTAL REGULATIONS.

SECTION 14. TRANSPORT INFORMATION

CONTACT PROFOLDIN FOR TRANSPORTATION INFORMATION.

SECTION 15. REGULATORY INFORMATION

EU ADDITIONAL CLASSIFICATION

S: 22 24/25

SAFETY STATEMENTS: DO NOT BREATHE DUST. AVOID CONTACT WITH SKIN

AND EYES.

US CLASSIFICATION AND LABEL TEXT

US STATEMENTS: CAUTION: AVOID CONTACT AND INHALATION. TARGET

ORGAN(S): CENTRAL NERVOUS SYSTEM. G.I. SYSTEM.

UNITED STATES REGULATORY INFORMATION

SARA LISTED: NO

TSCA INVENTORY ITEM: YES

CANADA REGULATORY INFORMATION

WHMIS CLASSIFICATION: THIS PRODUCT HAS BEEN CLASSIFIED IN

ACCORDANCE WITH THE HAZARD CRITERIA OF THE CPR, AND THE MSDS

CONTAINS ALL THE INFORMATION REQUIRED BY THE CPR.

DSL: NO

NDSL: NO

SECTION 16. OTHER INFORMATION

THIS PRODUCT IS FOR R&D USE ONLY. IT IS NOT FOR DRUG, HOUSEHOLD

OR OTHER USES. EMPLOYERS SHOULD USE THIS INFORMATION ONLY AS A

SUPPLEMENT TO OTHER INFORMATION GATHERED BY THEM, AND SHOULD MAKE

INDEPENDENT JUDGEMENT OF SUITABILITY OF THIS INFORMATION TO ENSURE

PROPER USE AND PROTECT THE HEALTH AND SAFETY OF EMPLOYEES. THIS

INFORMATION IS FURNISHED WITHOUT WARRANTY, AND ANY USE OF THE

PRODUCT NOT IN CONFORMANCE WITH THIS MATERIAL SAFETY DATA SHEET,

OR IN COMBINATION WITH ANY OTHER PRODUCT OR PROCESS, IS THE

RESPONSIBILITY OF THE USER. THE ABOVE INFORMATION IS BELIEVED

TO BE CORRECT BUT DOES NOT PURPORT TO BE ALL INCLUSIVE AND SHALL

BE USED ONLY AS A GUIDE. PROFOLDIN SHALL NOT BE HELD LIABLE FOR

ANY DAMAG RESULTING FROM HANDLING OR FROM CONTACT WITH THE ABOVE

PRODUCT.

SECTION 1. CHEMICAL IDENTIFICATION

CATALOG #: SFC01-10, SFC01, SFC02, SFC03, SFC04, SFC05, SFC06, SFC07, SFC08, SFC09, SFC10

PFC01, PFC02, PFC03, PFC04, PFC05, PFC06, PFC07, PFC08, PFC09, PFC10

NAME: GLYCEROL

APPROX 99%

SECTION 2. COMPOSITION/INFORMATION ON INGREDIENT

SUBSTANCE NAME

CAS #

SARA

GLYCEROL

56-81-5

FORMULA: C3H8O3

SYNONYMS GLYCEROL * CITIFLUOR AF 2 * GLYCERIN * GLYCERIN,

ANHYDROUS * GLYCERINE * GLYCERIN MIST

(ACGIH,OSHA) * GLYCERIN, SYNTHETIC * GLYCERITOL *

GLYCYL ALCOHOL * CLYZERIN, WASSERFREI (GERMAN) *

GROCOLENE * MOON * 1,2,3-PROPANETRIOL * OSMOGLYN

* STAR * SYNTHETIC GLYCERIN * 90 TECHNICAL

GLYCERINE * TRIHYDROXYPROPANE *

1,2,3-TRIHYDROXYPROPANE

RTECS NUMBER: MA8050000

SECTION 3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW

CAUTION: AVOID CONTACT AND INHALATION. TARGET ORGAN(S): KIDNEYS.

HMIS RATING

HEALTH: 1*

FLAMMABILITY: 0

REACTIVITY: 1

NFPA RATING

HEALTH: 1

FLAMMABILITY: 0

REACTIVITY: 1

*ADDITIONAL CHRONIC HAZARDS PRESENT.

FOR ADDITIONAL INFORMATION ON TOXICITY, PLEASE REFER TO SECTION 11.

SECTION 4. FIRST AID MEASURES

ORAL EXPOSURE

IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS

CONSCIOUS. CALL A PHYSICIAN.

INHALATION EXPOSURE

IF INHALED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT,

CALL A PHYSICIAN.

DERMAL EXPOSURE

IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS

AMOUNTS OF WATER.

EYE EXPOSURE

IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF

WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY

SEPARATING THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

SECTION 5. FIRE FIGHTING MEASURES

FLASH POINT

320 °F 160 °C METHOD: CLOSED CUP

EXPLOSION LIMITS

LOWER: 0.9 %

AUTOIGNITION TEMP

370 °C

FLAMMABILITY

N/A

EXTINGUISHING MEDIA

SUITABLE: WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER, OR

APPROPRIATE FOAM.

FIREFIGHTING

PROTECTIVE EQUIPMENT: WEAR SELF-CONTAINED BREATHING APPARATUS

AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND EYES.

SPECIFIC HAZARD(S): EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. ACCIDENTAL RELEASE MEASURES

PROCEDURE(S) OF PERSONAL PRECAUTION(S)

EXERCISE APPROPRIATE PRECAUTIONS TO MINIMIZE DIRECT CONTACT WITH

SKIN OR EYES AND PREVENT INHALATION OF VAPORS.

METHODS FOR CLEANING UP

ABSORB ON SAND OR VERMICULITE AND PLACE IN CLOSED CONTAINERS FOR

DISPOSAL. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL

PICKUP IS COMPLETE.

SECTION 7. HANDLING AND STORAGE

HANDLING

USER EXPOSURE: AVOID INHALATION. AVOID CONTACT WITH EYES, SKIN,

AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.

STORAGE

SUITABLE: KEEP TIGHTLY CLOSED.

SPECIAL REQUIREMENTS

HYGROSCOPIC.

SECTION 8. EXPOSURE CONTROLS / PPE

ENGINEERING CONTROLS

SAFETY SHOWER AND EYE BATH. MECHANICAL EXHAUST REQUIRED.

PERSONAL PROTECTIVE EQUIPMENT

HAND: PROTECTIVE GLOVES.

EYE: CHEMICAL SAFETY GOGGLES.

GENERAL HYGIENE MEASURES

WASH THOROUGHLY AFTER HANDLING.

EXPOSURE LIMITS, RTECS

COUNTRY SOURCE TYPE VALUE

USA USA ACGIH ACGIH TWA TWA 10 MG/M3 10 MG/M3

REMARKS: INHALABLE PARTICULATE

USA USA MSHA STANDARD MSHA

REMARKS: NUISANCE PARTICULATES (MIST). NUISANCE

USA USA OSHA. OSHA. PEL PEL 8H TWA 15 MG/M3, TOTAL DUST 8H

NEW ZEALAND OEL OEL

REMARKS: CHECK ACGIH TLV CHECK ACGIH TLV

EXPOSURE LIMITS

COUNTRY SOURCE TYPE VALUE

POLAND NDS 10 MG/M3

POLAND NDSCH -

POLAND NDSP

REMARKS: {OELS ARE VALID FOR AEROSOLS} AEROZOLE

SECTION 9. PHYSICAL/CHEMICAL PROPERTIES

APPEARANCE PHYSICAL STATE: LIQUID

PROPERTY VALUE AT TEMPERATURE OR PRESSURE

MOLECULAR WEIGHT 92.09 AMU

PH 5.5 - 8

BP/BP RANGE 182 °C 20 MMHG

MP/MP RANGE 20 °C

FREEZING POINT N/A

VAPOR PRESSURE < 1 MMHG 20 °C

VAPOR DENSITY 3.1 G/L

SATURATED VAPOR CONC. N/A

SG/DENSITY 1.262 G/CM3

BULK DENSITY N/A

ODOR THRESHOLD N/A

VOLATILE% N/A

VOC CONTENT N/A

WATER CONTENT < 0.1 %

SOLVENT CONTENT N/A

EVAPORATION RATE N/A

VISCOSITY N/A

SURFACE TENSION N/A

PARTITION COEFFICIENT N/A

DECOMPOSITION TEMP. N/A

FLASH POINT 320 °F 160 °C METHOD: CLOSED CUP

EXPLOSION LIMITS LOWER: 0.9 %

FLAMMABILITY N/A

AUTOIGNITION TEMP 370 °C

REFRACTIVE INDEX 1.474

OPTICAL ROTATION N/A

MISCELLANEOUS DATA N/A

SOLUBILITY SOLUBILITY IN WATER: 5 M IN H2O, 20°C

COMPLETE, COLORLESS

N/A = NOT AVAILABLE

SECTION 10. STABILITY AND REACTIVITY

STABILITY

STABLE: STABLE.

CONDITIONS TO AVOID: MOISTURE.

MATERIALS TO AVOID: STRONG BASES, STRONG OXIDIZING AGENTS.

HAZARDOUS DECOMPOSITION PRODUCTS

HAZARDOUS DECOMPOSITION PRODUCTS: CARBON MONOXIDE, CARBON DIOXIDE.

HAZARDOUS POLYMERIZATION

HAZARDOUS POLYMERIZATION: WILL NOT OCCUR

SECTION 11. TOXICOLOGICAL INFORMATION

ROUTE OF EXPOSURE

SKIN CONTACT: MAY CAUSE SKIN IRRITATION.

SKIN ABSORPTION: MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.

EYE CONTACT: MAY CAUSE EYE IRRITATION.

INHALATION: MAY BE HARMFUL IF INHALED. MATERIAL MAY BE

IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT.

INGESTION: MAY BE HARMFUL IF SWALLOWED.

TARGET ORGAN(S) OR SYSTEM(S)

KIDNEYS.

SIGNS AND SYMPTOMS OF EXPOSURE

PROLONGED EXPOSURE CAN CAUSE: NAUSEA, HEADACHE, AND VOMITING.

TOXICITY DATA

SKIN

RABBIT

> 10,000 MG/KG

LD50

ORAL

RAT

LD50

INHALATION

RAT

> 4 MG/KG

LC50

ORAL

RAT

12600 MG/KG

LD50

REMARKS: BEHAVIORAL: GENERAL ANESTHETIC. BEHAVIORAL: MUSCLE

WEAKNESS. LIVER: OTHER CHANGES.

INHALATION

RAT

> 570 MG/M3

LC50

INTRAPERITONEAL

RAT

4420 MG/KG

LD50

REMARKS: BEHAVIORAL: TOXIC PSYCHOSIS. CARDIAC: OTHER CHANGES.

KIDNEY, URETER, BLADDER: OTHER CHANGES.

SUBCUTANEOUS

RAT

100 MG/KG

LD50

INTRAVENOUS

RAT

5566 MG/KG

LD50

ORAL

MOUSE

4090 MG/KG

LD50

INTRAPERITONEAL

MOUSE

8700 MG/KG

LD50

REMARKS: BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN

RIGHTING REFLEX).

SUBCUTANEOUS

MOUSE

91 MG/KG

LD50

INTRAVENOUS

MOUSE

4250 MG/KG

LD50

ORAL

RABBIT

27000 MG/KG

LD50

SKIN

RABBIT

> 10000 MG/KG

LD50

INTRAVENOUS

RABBIT

53 GM/KG

LD50

ORAL

GUINEA PIG

7750 MG/KG

LD50

IRRITATION DATA

SKIN

RABBIT

500 MG

24H

REMARKS: MILD IRRITATION EFFECT

EYES

RABBIT

126 MG

REMARKS: MILD IRRITATION EFFECT

EYES

RABBIT

500 MG

24H

REMARKS: MILD IRRITATION EFFECT

CHRONIC EXPOSURE - MUTAGEN

SPECIES: HUMAN

DOSE: 200 MMOL/L

CELL TYPE: LYMPHOCYTE

MUTATION TEST: DNA INHIBITION

SPECIES: RAT

ROUTE: ORAL

DOSE: 1 GM/KG

MUTATION TEST: CYTOGENETIC ANALYSIS

CHRONIC EXPOSURE - REPRODUCTIVE HAZARD

SPECIES: RAT

DOSE: 100 MG/KG

ROUTE OF APPLICATION: ORAL

EXPOSURE TIME: (1D MALE)

RESULT: EFFECTS ON FERTILITY: POST-IMPLANTATION MORTALITY (E.G.,

DEAD AND/OR RESORBED IMPLANTS PER TOTAL NUMBER OF IMPLANTS).

SPECIES: RAT

DOSE: 280 MG/KG

ROUTE OF APPLICATION: INTRATESTICULAR

EXPOSURE TIME: (2D MALE)

RESULT: PATERNAL EFFECTS: SPERMATOGENESIS (INCLUDING GENETIC

MATERIAL, SPERM MORPHOLOGY,MOTILITY, AND COUNT). PATERNAL

EFFECTS: TESTES, EPIDIDYMIS, SPERM DUCT.

SPECIES: RAT

DOSE: 1600 MG/KG

ROUTE OF APPLICATION: INTRATESTICULAR

EXPOSURE TIME: (1D MALE)

RESULT: EFFECTS ON FERTILITY: MALE FERTILITY INDEX (E.G., #

MALES IMPREGNATING FEMALES PER # MALES EXPOSED TO FERTILE

NONPREGNANT FEMALES).

SPECIES: RAT

DOSE: 862 MG/KG

ROUTE OF APPLICATION: INTRATESTICULAR

EXPOSURE TIME: (1D MALE)

RESULT: PATERNAL EFFECTS: SPERMATOGENESIS (INCLUDING GENETIC

MATERIAL, SPERM MORPHOLOGY,MOTILITY, AND COUNT).

SPECIES: MONKEY

DOSE: 119 MG/KG

ROUTE OF APPLICATION: INTRATESTICULAR

EXPOSURE TIME: (1D MALE)

RESULT: PATERNAL EFFECTS: SPERMATOGENESIS (INCLUDING GENETIC

MATERIAL, SPERM MORPHOLOGY,MOTILITY, AND COUNT). PATERNAL

EFFECTS: TESTES, EPIDIDYMIS, SPERM DUCT.

SECTION 12. ECOLOGICAL INFORMATION

NO DATA AVAILABLE.

ACUTE ECOTOXICITY TESTS

TEST TYPE: LC50 FISH

SPECIES: OTHER FISH

VALUE: > 100,100 MG/L

TEST TYPE: LC50 FISH

SPECIES: PIMEPHALES PROMELAS (FATHEAD MINNOW)

VALUE: 44,000 MG/L

TEST TYPE: LC50 FISH

SPECIES: CARASSIUS AURATUS (GOLDFISH)

VALUE: > 5,000 MG/L

SECTION 13. DISPOSAL CONSIDERATIONS

APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION

CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE

OF THIS MATERIAL. DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE

SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN

AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE, AND LOCAL

ENVIRONMENTAL REGULATIONS.

SECTION 14. TRANSPORT INFORMATION

CONTACT PROFOLDIN FOR TRANSPORTATION INFORMATION.

SECTION 15. REGULATORY INFORMATION

EU ADDITIONAL CLASSIFICATION

S: 23 24/25

SAFETY STATEMENTS: DO NOT BREATHE VAPOR. AVOID CONTACT WITH SKIN

AND EYES.

US CLASSIFICATION AND LABEL TEXT

US STATEMENTS: CAUTION: AVOID CONTACT AND INHALATION. TARGET

ORGAN(S): KIDNEYS.

UNITED STATES REGULATORY INFORMATION

SARA LISTED: NO

TSCA INVENTORY ITEM: YES YES

CANADA REGULATORY INFORMATION

WHMIS CLASSIFICATION: THIS PRODUCT HAS BEEN CLASSIFIED IN

ACCORDANCE WITH THE HAZARD CRITERIA OF THE CPR, AND THE MSDS

CONTAINS ALL THE INFORMATION REQUIRED BY THE CPR.

DSL: YES

NDSL: NO

SECTION 16. OTHER INFORMATION

THIS PRODUCT IS FOR R&D USE ONLY. IT IS NOT FOR DRUG, HOUSEHOLD

OR OTHER USES. EMPLOYERS SHOULD USE THIS INFORMATION ONLY AS A

SUPPLEMENT TO OTHER INFORMATION GATHERED BY THEM, AND SHOULD MAKE

INDEPENDENT JUDGEMENT OF SUITABILITY OF THIS INFORMATION TO ENSURE

PROPER USE AND PROTECT THE HEALTH AND SAFETY OF EMPLOYEES. THIS

INFORMATION IS FURNISHED WITHOUT WARRANTY, AND ANY USE OF THE

PRODUCT NOT IN CONFORMANCE WITH THIS MATERIAL SAFETY DATA SHEET,

OR IN COMBINATION WITH ANY OTHER PRODUCT OR PROCESS, IS THE

RESPONSIBILITY OF THE USER. THE ABOVE INFORMATION IS BELIEVED

TO BE CORRECT BUT DOES NOT PURPORT TO BE ALL INCLUSIVE AND SHALL

BE USED ONLY AS A GUIDE. PROFOLDIN SHALL NOT BE HELD LIABLE FOR

ANY DAMAG RESULTING FROM HANDLING OR FROM CONTACT WITH THE ABOVE

PRODUCT.

SECTION 1. CHEMICAL IDENTIFICATION

CATALOG #: SFC01-10, SFC01, SFC02, SFC03, SFC04, SFC05, SFC06, SFC07, SFC08, SFC09, SFC10

PFC01, PFC02, PFC03, PFC04, PFC05, PFC06, PFC07, PFC08, PFC09, PFC10

NAME: SEPHADEX

SECTION 2. COMPOSITION/INFORMATION ON INGREDIENT

SUBSTANCE NAME

CAS #

SARA

PDX G.F. 25 (100-300)

9041-35-4

SECTION 3. HAZARDS IDENTIFICATION

HMIS RATING

HEALTH: 0

FLAMMABILITY: 0

REACTIVITY: 0

NFPA RATING

HEALTH: 0

FLAMMABILITY: 0

REACTIVITY: 0

FOR ADDITIONAL INFORMATION ON TOXICITY, PLEASE REFER TO SECTION 11.

SECTION 4. FIRST AID MEASURES

ORAL EXPOSURE

IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS

CONSCIOUS. CALL A PHYSICIAN.

INHALATION EXPOSURE

IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE

ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.

DERMAL EXPOSURE

IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS

AMOUNTS OF WATER.

EYE EXPOSURE

IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS

OF WATER FOR AT LEAST 15 MINUTES.

SECTION 5. FIRE FIGHTING MEASURES

FLASH POINT

N/A

AUTOIGNITION TEMP

N/A

FLAMMABILITY

N/A

EXTINGUISHING MEDIA

SUITABLE: WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER, OR

APPROPRIATE FOAM.

FIREFIGHTING

PROTECTIVE EQUIPMENT: WEAR SELF-CONTAINED BREATHING APPARATUS

AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND EYES.

SPECIFIC HAZARD(S): EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. ACCIDENTAL RELEASE MEASURES

PROCEDURE(S) OF PERSONAL PRECAUTION(S)

EXERCISE APPROPRIATE PRECAUTIONS TO MINIMIZE DIRECT CONTACT WITH

SKIN OR EYES AND PREVENT INHALATION OF DUST.

METHODS FOR CLEANING UP

SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID

RAISING DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL

PICKUP IS COMPLETE.

SECTION 7. HANDLING AND STORAGE

HANDLING

USER EXPOSURE: AVOID INHALATION. AVOID CONTACT WITH EYES, SKIN,

AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.

STORAGE

SUITABLE: KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE.

SPECIAL REQUIREMENTS

MOISTURE SENSITIVE.

SECTION 8. EXPOSURE CONTROLS / PPE

ENGINEERING CONTROLS

SAFETY SHOWER AND EYE BATH. MECHANICAL EXHAUST REQUIRED.

PERSONAL PROTECTIVE EQUIPMENT

RESPIRATORY: GOVERNMENT APPROVED RESPIRATOR.

HAND: COMPATIBLE CHEMICAL-RESISTANT GLOVES.

EYE: CHEMICAL SAFETY GOGGLES.

GENERAL HYGIENE MEASURES

WASH THOROUGHLY AFTER HANDLING. WASH CONTAMINATED CLOTHING BEFORE

REUSE.

SECTION 9. PHYSICAL/CHEMICAL PROPERTIES

APPEARANCE COLOR: WHITE

FORM: POWDER

PROPERTY VALUE AT TEMPERATURE OR PRESSURE

MOLECULAR WEIGHT N/A

PH N/A

BP/BP RANGE N/A

MP/MP RANGE N/A

FREEZING POINT N/A

VAPOR PRESSURE N/A

VAPOR DENSITY N/A

SATURATED VAPOR CONC. N/A

SG/DENSITY N/A

BULK DENSITY N/A

ODOR THRESHOLD N/A

VOLATILE% N/A

VOC CONTENT N/A

WATER CONTENT N/A

SOLVENT CONTENT N/A

EVAPORATION RATE N/A

VISCOSITY N/A

SURFACE TENSION N/A

PARTITION COEFFICIENT N/A

DECOMPOSITION TEMP. N/A

FLASH POINT N/A

EXPLOSION LIMITS N/A

FLAMMABILITY N/A

AUTOIGNITION TEMP N/A

REFRACTIVE INDEX N/A

OPTICAL ROTATION N/A

MISCELLANEOUS DATA N/A

SOLUBILITY N/A

N/A = NOT AVAILABLE

SECTION 10. STABILITY AND REACTIVITY

STABILITY

CONDITIONS TO AVOID: MOISTURE.

MATERIALS TO AVOID: STRONG OXIDIZING AGENTS.

HAZARDOUS DECOMPOSITION PRODUCTS

HAZARDOUS DECOMPOSITION PRODUCTS: CARBON MONOXIDE, CARBON DIOXIDE.

HAZARDOUS POLYMERIZATION

HAZARDOUS POLYMERIZATION: WILL NOT OCCUR

SECTION 11. TOXICOLOGICAL INFORMATION

ROUTE OF EXPOSURE

SKIN CONTACT: MAY CAUSE SKIN IRRITATION.

SKIN ABSORPTION: MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.

EYE CONTACT: MAY CAUSE EYE IRRITATION.

INHALATION: MAY BE HARMFUL IF INHALED. MATERIAL MAY BE

IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT.

INGESTION: MAY BE HARMFUL IF SWALLOWED.

SIGNS AND SYMPTOMS OF EXPOSURE

TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND

TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.

SECTION 12. ECOLOGICAL INFORMATION

NO DATA AVAILABLE.

SECTION 13. DISPOSAL CONSIDERATIONS

APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION

DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN

IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND

SCRUBBER. OBSERVE ALL FEDERAL, STATE, AND LOCAL ENVIRONMENTAL

REGULATIONS.

SECTION 14. TRANSPORT INFORMATION

CONTACT PROFOLDIN FOR TRANSPORTATION INFORMATION.

SECTION 15. REGULATORY INFORMATION

EU ADDITIONAL CLASSIFICATION

S: 22

SAFETY STATEMENTS: DO NOT BREATHE DUST.

UNITED STATES REGULATORY INFORMATION

SARA LISTED: NO

CANADA REGULATORY INFORMATION

WHMIS CLASSIFICATION: THIS PRODUCT HAS BEEN CLASSIFIED IN

ACCORDANCE WITH THE HAZARD CRITERIA OF THE CPR, AND THE MSDS

CONTAINS ALL THE INFORMATION REQUIRED BY THE CPR.

DSL: NO

NDSL: NO

SECTION 16. OTHER INFORMATION

THIS PRODUCT IS FOR R&D USE ONLY. IT IS NOT FOR DRUG, HOUSEHOLD

OR OTHER USES. EMPLOYERS SHOULD USE THIS INFORMATION ONLY AS A

SUPPLEMENT TO OTHER INFORMATION GATHERED BY THEM, AND SHOULD MAKE

INDEPENDENT JUDGEMENT OF SUITABILITY OF THIS INFORMATION TO ENSURE

PROPER USE AND PROTECT THE HEALTH AND SAFETY OF EMPLOYEES. THIS

INFORMATION IS FURNISHED WITHOUT WARRANTY, AND ANY USE OF THE

PRODUCT NOT IN CONFORMANCE WITH THIS MATERIAL SAFETY DATA SHEET,

OR IN COMBINATION WITH ANY OTHER PRODUCT OR PROCESS, IS THE

RESPONSIBILITY OF THE USER. THE ABOVE INFORMATION IS BELIEVED

TO BE CORRECT BUT DOES NOT PURPORT TO BE ALL INCLUSIVE AND SHALL

BE USED ONLY AS A GUIDE. PROFOLDIN SHALL NOT BE HELD LIABLE FOR

ANY DAMAG RESULTING FROM HANDLING OR FROM CONTACT WITH THE ABOVE

PRODUCT.

SECTION 1. CHEMICAL IDENTIFICATION

CATALOG #: SFC01-10, SFC01, SFC02, SFC03, SFC04, SFC05, SFC06, SFC07, SFC08, SFC09, SFC10

PFC01, PFC02, PFC03, PFC04, PFC05, PFC06, PFC07, PFC08, PFC09, PFC10

NAME: DIMETHYL SULFOXIDE

REAGENT

SECTION 2. COMPOSITION/INFORMATION ON INGREDIENT

SUBSTANCE NAME

CAS #

SARA

DIMETHYL SULFOXIDE

67-68-5

FORMULA: C2H6OS

SYNONYMS A 10846 * DELTAN * DEMESO * DEMASORB * DEMAVET *

DEMSODROX * DERMASORB * DIMETHYL SULFOXIDE *

DIMETHYL SULPHOXIDE * DIMEXIDE *

DIPIRARTRIL-TROPICO * DMS-70 * DMS-90 * DMSO *

DOLICUR * DOMOSO * DROMISOL * DURASORB * GAMASOL

90 * HYADUR * INFILTRINA * M 176 * METHANE,

SULFINYLBIS- * METHYLSULFINYLMETHANE * NSC-763 *

RIMSO-50 * SOMIPRONT * SQ 9453 *

SULFINYLBIS(METHANE) * SYNTEXAN * TOPSYM

RTECS NUMBER: PV6210000

SECTION 3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW

COMBUSTIBLE. READILY ABSORBED THROUGH SKIN. TARGET ORGAN(S): EYES.

SKIN.

HMIS RATING

HEALTH: 0*

FLAMMABILITY: 2

REACTIVITY: 1

NFPA RATING

HEALTH: 0

FLAMMABILITY: 2

REACTIVITY: 1

*ADDITIONAL CHRONIC HAZARDS PRESENT.

FOR ADDITIONAL INFORMATION ON TOXICITY, PLEASE REFER TO SECTION 11.

SECTION 4. FIRST AID MEASURES

ORAL EXPOSURE

IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS

CONSCIOUS. CALL A PHYSICIAN.

INHALATION EXPOSURE

IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE

ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.

DERMAL EXPOSURE

IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS

AMOUNTS OF WATER.

EYE EXPOSURE

IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS

OF WATER FOR AT LEAST 15 MINUTES.

SECTION 5. FIRE FIGHTING MEASURES

FLASH POINT

188.6 °F 87 °C METHOD: CLOSED CUP

EXPLOSION LIMITS

LOWER: 3.5 % UPPER: 42 %

AUTOIGNITION TEMP

301 °C

FLAMMABILITY

N/A

EXTINGUISHING MEDIA

SUITABLE: WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER, OR

APPROPRIATE FOAM.

FIREFIGHTING

PROTECTIVE EQUIPMENT: WEAR SELF-CONTAINED BREATHING APPARATUS

AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND EYES.

SPECIFIC HAZARD(S): COMBUSTIBLE LIQUID. EMITS TOXIC FUMES UNDER

FIRE CONDITIONS.

SECTION 6. ACCIDENTAL RELEASE MEASURES

PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL

EVACUATE AREA.

PROCEDURE(S) OF PERSONAL PRECAUTION(S)

WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS, AND

HEAVY RUBBER GLOVES.

METHODS FOR CLEANING UP

COVER WITH DRY-LIME, SAND, OR SODA ASH. PLACE IN COVERED

CONTAINERS USING NON-SPARKING TOOLS AND TRANSPORT OUTDOORS.

VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS

COMPLETE.

ENVIRONMENTAL PRECAUTION(S)

AVOID CONTAMINATING SEWERS AND WATERWAYS WITH THIS MATERIAL.

SECTION 7. HANDLING AND STORAGE

HANDLING

USER EXPOSURE: DO NOT BREATHE VAPOR. AVOID CONTACT WITH DMSO

SOLUTIONS CONTAINING TOXIC MATERIALS OR MATERIALS WITH UNKNOWN

TOXICOLOGICAL PROPERTIES. DIMETHYL SULFOXIDE IS READILY ABSORBED

THROUGH SKIN AND MAY CARRY SUCH MATERIALS INTO THE BODY. AVOID

PROLONGED OR REPEATED EXPOSURE.

STORAGE

SUITABLE: STORE UNDER INERT GAS. KEEP TIGHTLY CLOSED. KEEP AWAY

FROM HEAT AND OPEN FLAME. STORE IN A COOL DRY PLACE.

SPECIAL REQUIREMENTS

STORE UNDER INERT GAS. HYGROSCOPIC.

SECTION 8. EXPOSURE CONTROLS / PPE

ENGINEERING CONTROLS

SAFETY SHOWER AND EYE BATH. MECHANICAL EXHAUST REQUIRED.

PERSONAL PROTECTIVE EQUIPMENT

RESPIRATORY: GOVERNMENT APPROVED RESPIRATOR.

HAND: COMPATIBLE CHEMICAL-RESISTANT GLOVES.

EYE: CHEMICAL SAFETY GOGGLES.

SKIN-SPECIFIC: CHEMICAL RESISTANT APRON.

GENERAL HYGIENE MEASURES

WASH CONTAMINATED CLOTHING BEFORE REUSE. WASH THOROUGHLY AFTER

HANDLING.

SECTION 9. PHYSICAL/CHEMICAL PROPERTIES

APPEARANCE PHYSICAL STATE: CLEAR LIQUID

COLOR: COLORLESS

PROPERTY VALUE AT TEMPERATURE OR PRESSURE

MOLECULAR WEIGHT 78.13 AMU

PH N/A

BP/BP RANGE 189 °C

MP/MP RANGE 18.4 °C

FREEZING POINT N/A

VAPOR PRESSURE 0.42 MMHG 20 °C

VAPOR DENSITY 2.7 G/L

SATURATED VAPOR CONC. N/A

SG/DENSITY 1.1 G/CM3

BULK DENSITY N/A

ODOR THRESHOLD N/A

VOLATILE% N/A

VOC CONTENT N/A

WATER CONTENT N/A

SOLVENT CONTENT N/A

EVAPORATION RATE N/A

VISCOSITY 0.002 PAS 20 °C

SURFACE TENSION N/A

PARTITION COEFFICIENT LOG KOW: -2.03

DECOMPOSITION TEMP. > 190 °C

FLASH POINT 188.6 °F 87 °C METHOD: CLOSED CUP

EXPLOSION LIMITS LOWER: 3.5 %

UPPER: 42 %

FLAMMABILITY N/A

AUTOIGNITION TEMP 301 °C

REFRACTIVE INDEX 1.479

OPTICAL ROTATION N/A

MISCELLANEOUS DATA N/A

SOLUBILITY SOLUBILITY IN WATER: MISCIBLE.

OTHER SOLVENTS: ALCOHOLS, ETHYL ETHERS

N/A = NOT AVAILABLE

SECTION 10. STABILITY AND REACTIVITY

STABILITY

STABLE: STABLE.

CONDITIONS TO AVOID: MOISTURE.

MATERIALS TO AVOID: ACID CHLORIDES, PHOSPHORUS HALIDES, STRONG

ACIDS, STRONG OXIDIZING AGENTS, STRONG REDUCING AGENTS.

HAZARDOUS DECOMPOSITION PRODUCTS

HAZARDOUS DECOMPOSITION PRODUCTS: CARBON MONOXIDE, CARBON DIOXIDE,

SULFUR OXIDES.

HAZARDOUS EXOTHERMIC REACTIONS

HAZARDOUS EXOTHERMIC REACTIONS: METHYL SULFOXIDE (DMSO) UNDERGOES

A VIOLENT EXOTHERMIC REACTION ON MIXING WITH COPPER WOOL AND

TRICHLOROACETIC ACID. ON MIXING WITH POTASSIUM PERMANGANATE IT

WILL FLASH INSTANTANEOUSLY. IT REACTS VIOLENTLY WITH: ACID

HALIDES, CYANURIC CHLORIDE, SILICON TETRACHLORIDE, PHOSPHORUS

TRICHLORIDE AND TRIOXIDE, THIONYL CHLORIDE, MAGNESIUM PERCHLORATE,

SILVER FLUORIDE, METHYL BROMIDE, IODINE PENTAFLUORIDE, NITROGEN

PERIODATE, DIBORANE, SODIUM HYDRIDE, AND PERCHLORIC AND PERIODIC

ACIDS. WHEN HEATED ABOVE ITS BOILING POINT METHYL SULFOXIDE

DEGRADES GIVING OFF FORMALDEHYDE, METHYL MERCAPTAN, AND SULFUR

DIOXIDE.

HAZARDOUS POLYMERIZATION

HAZARDOUS POLYMERIZATION: WILL NOT OCCUR

SECTION 11. TOXICOLOGICAL INFORMATION

ROUTE OF EXPOSURE

SKIN CONTACT: MAY CAUSE SKIN IRRITATION.

SKIN ABSORPTION: MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.

READILY ABSORBED THROUGH SKIN.

EYE CONTACT: MAY CAUSE EYE IRRITATION.

INHALATION: MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND

UPPER RESPIRATORY TRACT. MAY BE HARMFUL IF INHALED.

INGESTION: MAY BE HARMFUL IF SWALLOWED.

TARGET ORGAN(S) OR SYSTEM(S)

EYES. SKIN.

CONDITIONS AGGRAVATED BY EXPOSURE

AVOID CONTACT WITH DMSO SOLUTIONS CONTAINING TOXIC MATERIALS OR

MATERIALS WITH UNKNOWN TOXICOLOGICAL PROPERTIES. DIMETHYL

SULFOXIDE IS READILY ABSORBED THROUGH SKIN AND MAY CARRY SUCH

MATERIALS INTO THE BODY.

TOXICITY DATA

INHALATION

RAT

40,250 PPM

LC50

ORAL

RAT

3,300 MG/KG

LD50

SKIN

RABBIT

> 5,000 MG/KG

LD50

ORAL

RAT

14500 MG/KG

LD50

REMARKS: SENSE ORGANS AND SPECIAL SENSES (NOSE, EYE, EAR, AND

TASTE): EYE: HEMORRHAGE. SENSE ORGANS AND SPECIAL SENSES (NOSE,

EYE, EAR, AND TASTE): EYE: CONJUNCTIVE IRRITATION.

SKIN

RAT

40000 MG/KG

LD50

INTRAPERITONEAL

RAT

8200 MG/KG

LD50

SUBCUTANEOUS

RAT

12 GM/KG

LD50

REMARKS: BEHAVIORAL: CHANGE IN MOTOR ACTIVITY (SPECIFIC ASSAY).

LUNGS, THORAX, OR RESPIRATION: DYSPNEA.

INTRAVENOUS

RAT

5360 MG/KG

LD50

REMARKS: BEHAVIORAL: TREMOR. BEHAVIORAL: MUSCLE WEAKNESS. LUNGS,

THORAX, OR RESPIRATION: DYSPNEA.

ORAL

MOUSE

7920 MG/KG

LD50

SKIN

MOUSE

50000 MG/KG

LD50

INTRAPERITONEAL

MOUSE

2500 MG/KG

LD50

SUBCUTANEOUS

MOUSE

14 GM/KG

LD50

REMARKS: BEHAVIORAL: CHANGE IN MOTOR ACTIVITY (SPECIFIC ASSAY).

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES. KIDNEY, URETER,

BLADDER: HEMATURIA.

INTRAVENOUS

MOUSE

3100 MG/KG

LD50

REMARKS: SENSE ORGANS AND SPECIAL SENSES (NOSE, EYE, EAR, AND

TASTE): EYE: HEMORRHAGE. SENSE ORGANS AND SPECIAL SENSES (NOSE,

EYE, EAR, AND TASTE): EYE: CONJUNCTIVE IRRITATION.

ORAL

DOG

> 10000 MG/KG

LD50

INTRAVENOUS

DOG

2500 MG/KG

LD50

REMARKS: CARDIAC: OTHER CHANGES. KIDNEY, URETER,

BLADDER: HEMATURIA. KIDNEY, URETER, BLADDER: OTHER CHANGES.

ORAL

CHICKEN

12000 MG/KG

LD50

ORAL

MAMMAL

21400 MG/KG

LD50

ORAL

BIRD (WILD)

100 MG/KG

LD50

IRRITATION DATA

SKIN

RABBIT

4 HOURS

REMARKS: NO IRRITATION EFFECT

EYES

RABBIT

REMARKS: MILD IRRITATION EFFECT

SKIN

RABBIT

10 MG

24H

REMARKS: OPEN IRRITATION TEST

SKIN

RABBIT

500 MG

24H

REMARKS: MILD IRRITATION EFFECT

EYES

RABBIT

100 MG

EYES

RABBIT

500 MG

24H

REMARKS: MILD IRRITATION EFFECT

CHRONIC EXPOSURE - CARCINOGEN

SPECIES: RAT

ROUTE OF APPLICATION: ORAL

DOSE: 59 GM/KG

EXPOSURE TIME: 81W

FREQUENCY: I

RESULT: TUMORIGENIC: EQUIVOCAL TUMORIGENIC AGENT BY RTECS

CRITERIA. SKIN AND APPENDAGES: OTHER: TUMORS.

SPECIES: RAT

ROUTE OF APPLICATION: SUBCUTANEOUS

DOSE: 220 GM/KG

EXPOSURE TIME: 82W

FREQUENCY: I

RESULT: TUMORIGENIC: EQUIVOCAL TUMORIGENIC AGENT BY RTECS

CRITERIA. SKIN AND APPENDAGES: OTHER: TUMORS.

SPECIES: MOUSE

ROUTE OF APPLICATION: ORAL

DOSE: 65340 MG/KG

EXPOSURE TIME: 66W

FREQUENCY: I

RESULT: TUMORIGENIC: EQUIVOCAL TUMORIGENIC AGENT BY RTECS

CRITERIA. BLOOD: LEUKEMIA SKIN AND APPENDAGES: OTHER: TUMORS.

SPECIES: MOUSE

ROUTE OF APPLICATION: SUBCUTANEOUS

DOSE: 66 GM/KG

EXPOSURE TIME: 66W

FREQUENCY: I

RESULT: TUMORIGENIC: EQUIVOCAL TUMORIGENIC AGENT BY RTECS

CRITERIA. LUNGS, THORAX, OR RESPIRATION: TUMORS. SKIN AND

APPENDAGES: OTHER: TUMORS.

CHRONIC EXPOSURE - TERATOGEN

SPECIES: MOUSE

DOSE: 210 GM/KG

ROUTE OF APPLICATION: INTRAPERITONEAL

EXPOSURE TIME: (6-12D PREG)

RESULT: SPECIFIC DEVELOPMENTAL ABNORMALITIES: CENTRAL NERVOUS

SYSTEM. SPECIFIC DEVELOPMENTAL ABNORMALITIES: MUSCULOSKELETAL

SYSTEM.

SPECIES: MOUSE

DOSE: 5500 MG/KG

ROUTE OF APPLICATION: INTRAPERITONEAL

EXPOSURE TIME: (10D PREG)

RESULT: EFFECTS ON EMBRYO OR FETUS: FETOTOXICITY (EXCEPT DEATH,

E.G., STUNTED FETUS). SPECIFIC DEVELOPMENTAL ABNORMALITIES:

MUSCULOSKELETAL SYSTEM.

SPECIES: HAMSTER

DOSE: 11 GM/KG

ROUTE OF APPLICATION: ORAL

EXPOSURE TIME: (7D PREG)

RESULT: SPECIFIC DEVELOPMENTAL ABNORMALITIES: CENTRAL NERVOUS

SYSTEM. SPECIFIC DEVELOPMENTAL ABNORMALITIES: MUSCULOSKELETAL

SYSTEM.

SPECIES: HAMSTER

DOSE: 5500 MG/KG

ROUTE OF APPLICATION: INTRAPERITONEAL

EXPOSURE TIME: (8D PREG)

RESULT: SPECIFIC DEVELOPMENTAL ABNORMALITIES: MUSCULOSKELETAL

SYSTEM. SPECIFIC DEVELOPMENTAL ABNORMALITIES: CENTRAL NERVOUS

SYSTEM. SPECIFIC DEVELOPMENTAL ABNORMALITIES: CRANIOFACIAL

(INCLUDING NOSE AND TONGUE).

SPECIES: HAMSTER

DOSE: 4400 MG/KG

ROUTE OF APPLICATION: INTRAPERITONEAL

EXPOSURE TIME: (8D PREG)

RESULT: EFFECTS ON EMBRYO OR FETUS: FETAL DEATH. SPECIFIC

DEVELOPMENTAL ABNORMALITIES: CENTRAL NERVOUS SYSTEM.

SPECIES: HAMSTER

DOSE: 2500 MG/KG

ROUTE OF APPLICATION: INTRAVENOUS

EXPOSURE TIME: (8D PREG)

RESULT: SPECIFIC DEVELOPMENTAL ABNORMALITIES: CENTRAL NERVOUS

SYSTEM. SPECIFIC DEVELOPMENTAL ABNORMALITIES: CRANIOFACIAL

(INCLUDING NOSE AND TONGUE). SPECIFIC DEVELOPMENTAL

ABNORMALITIES: MUSCULOSKELETAL SYSTEM.

SPECIES: HAMSTER

DOSE: 2500 MG/KG

ROUTE OF APPLICATION: INTRAVENOUS

EXPOSURE TIME: (8D PREG)

RESULT: SPECIFIC DEVELOPMENTAL ABNORMALITIES: OTHER

DEVELOPMENTAL ABNORMALITIES.

CHRONIC EXPOSURE - MUTAGEN

SPECIES: HUMAN

DOSE: 140 MMOL/L

CELL TYPE: LYMPHOCYTE

MUTATION TEST: OTHER MUTATION TEST SYSTEMS

SPECIES: RAT

ROUTE: INTRAPERITONEAL

DOSE: 25 GM/KG

EXPOSURE TIME: 5D

MUTATION TEST: CYTOGENETIC ANALYSIS

SPECIES: MOUSE

ROUTE: INTRAPERITONEAL

DOSE: 75 MMOL/KG

MUTATION TEST: DNA DAMAGE

SPECIES: MOUSE

DOSE: 93 GM/L

CELL TYPE: LYMPHOCYTE

MUTATION TEST: CYTOGENETIC ANALYSIS

SPECIES: MOUSE

DOSE: 1 MOL/L

CELL TYPE: LYMPHOCYTE

MUTATION TEST: MUTATION IN MAMMALIAN SOMATIC CELLS.

SPECIES: HAMSTER

DOSE: 19 PPH

CELL TYPE: OVARY

MUTATION TEST: CYTOGENETIC ANALYSIS

SPECIES: HAMSTER

DOSE: 1 PPH

CELL TYPE: LUNG

MUTATION TEST: CYTOGENETIC ANALYSIS

CHRONIC EXPOSURE - REPRODUCTIVE HAZARD

SPECIES: RAT

DOSE: 56 GM/KG

ROUTE OF APPLICATION: INTRAPERITONEAL

EXPOSURE TIME: (6-12D PREG)

RESULT: EFFECTS ON FERTILITY: ABORTION.

SPECIES: RAT

DOSE: 6600 MG/KG

ROUTE OF APPLICATION: INTRAPERITONEAL

EXPOSURE TIME: (7-15D PREG)

RESULT: EFFECTS ON FERTILITY: POST-IMPLANTATION MORTALITY (E.G.,

DEAD AND/OR RESORBED IMPLANTS PER TOTAL NUMBER OF IMPLANTS).

SPECIES: RAT

DOSE: 30750 MG/KG

ROUTE OF APPLICATION: SUBCUTANEOUS

EXPOSURE TIME: (8-10D PREG)

RESULT: EFFECTS ON FERTILITY: POST-IMPLANTATION MORTALITY (E.G.,

DEAD AND/OR RESORBED IMPLANTS PER TOTAL NUMBER OF IMPLANTS).

EFFECTS ON FERTILITY: LITTER SIZE (E.G.; # FETUSES PER LITTER;

MEASURED BEFORE BIRTH).

SPECIES: MOUSE

DOSE: 16 MG/KG

ROUTE OF APPLICATION: ORAL

EXPOSURE TIME: (5-9D PREG)

RESULT: EFFECTS ON FERTILITY: PRE-IMPLANTATION MORTALITY (E.G.,

REDUCTION IN NUMBER OF IMPLANTS PER FEMALE; TOTAL NUMBER OF

IMPLANTS PER CORPORA LUTEA). EFFECTS ON EMBRYO OR FETUS:

FETOTOXICITY (EXCEPT DEATH, E.G., STUNTED FETUS). SPECIFIC

DEVELOPMENTAL ABNORMALITIES: MUSCULOSKELETAL SYSTEM.

SPECIES: MOUSE

DOSE: 8250 MG/KG

ROUTE OF APPLICATION: INTRAPERITONEAL

EXPOSURE TIME: (10D PREG)

RESULT: EFFECTS ON FERTILITY: POST-IMPLANTATION MORTALITY (E.G.,

DEAD AND/OR RESORBED IMPLANTS PER TOTAL NUMBER OF IMPLANTS).

SPECIES: MOUSE

DOSE: 240 GM/KG

ROUTE OF APPLICATION: INTRAVENOUS

EXPOSURE TIME: (1-20D PREG)

RESULT: EFFECTS ON FERTILITY: POST-IMPLANTATION MORTALITY (E.G.,

DEAD AND/OR RESORBED IMPLANTS PER TOTAL NUMBER OF IMPLANTS).

SECTION 12. ECOLOGICAL INFORMATION

ACUTE ECOTOXICITY TESTS

TEST TYPE: LC50 FISH

SPECIES: ONCHORHYNCHUS MYKISS (RAINBOW TROUT)

TIME: 96 H

VALUE: 35,000 MG/L

TEST TYPE: EC50 DAPHNIA

SPECIES: DAPHNIA PULEX

VALUE: 27,500 MG/L

TEST TYPE: EC50 ALGAE

SPECIES: LEPOMIS MACROCHIRUS (BLUEGILL)

TIME: 96 H

VALUE: > 400,000 MG/L

TEST TYPE: LC50 FISH

SPECIES: PIMEPHALES PROMELAS (FATHEAD MINNOW)

TIME: 96 H

VALUE: 34,000 MG/L

SECTION 13. DISPOSAL CONSIDERATIONS

APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION

CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE

OF THIS MATERIAL. THIS COMBUSTIBLE MATERIAL MAY BE BURNED IN A

CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.

OBSERVE ALL FEDERAL, STATE, AND LOCAL ENVIRONMENTAL REGULATIONS.

SECTION 14. TRANSPORT INFORMATION

CONTACT PROFOLDIN FOR TRANSPORTATION INFORMATION.

SECTION 15. REGULATORY INFORMATION

US CLASSIFICATION AND LABEL TEXT

US STATEMENTS: COMBUSTIBLE. READILY ABSORBED THROUGH SKIN.

TARGET ORGAN(S): EYES. SKIN.

UNITED STATES REGULATORY INFORMATION

SARA LISTED: NO

TSCA INVENTORY ITEM: YES

CANADA REGULATORY INFORMATION

WHMIS CLASSIFICATION: THIS PRODUCT HAS BEEN CLASSIFIED IN

ACCORDANCE WITH THE HAZARD CRITERIA OF THE CPR, AND THE MSDS

CONTAINS ALL THE INFORMATION REQUIRED BY THE CPR.

DSL: YES

NDSL: NO

SECTION 16. OTHER INFORMATION

THIS PRODUCT IS FOR R&D USE ONLY. IT IS NOT FOR DRUG, HOUSEHOLD

OR OTHER USES. EMPLOYERS SHOULD USE THIS INFORMATION ONLY AS A

SUPPLEMENT TO OTHER INFORMATION GATHERED BY THEM, AND SHOULD MAKE

INDEPENDENT JUDGEMENT OF SUITABILITY OF THIS INFORMATION TO ENSURE

PROPER USE AND PROTECT THE HEALTH AND SAFETY OF EMPLOYEES. THIS

INFORMATION IS FURNISHED WITHOUT WARRANTY, AND ANY USE OF THE

PRODUCT NOT IN CONFORMANCE WITH THIS MATERIAL SAFETY DATA SHEET,

OR IN COMBINATION WITH ANY OTHER PRODUCT OR PROCESS, IS THE

RESPONSIBILITY OF THE USER. THE ABOVE INFORMATION IS BELIEVED

TO BE CORRECT BUT DOES NOT PURPORT TO BE ALL INCLUSIVE AND SHALL

BE USED ONLY AS A GUIDE. PROFOLDIN SHALL NOT BE HELD LIABLE FOR

ANY DAMAG RESULTING FROM HANDLING OR FROM CONTACT WITH THE ABOVE

PRODUCT.

SECTION 1. CHEMICAL IDENTIFICATION

CATALOG #: SFC01-10, SFC01, SFC02, SFC03, SFC04, SFC05, SFC06, SFC07, SFC08, SFC09, SFC10

PFC01, PFC02, PFC03, PFC04, PFC05, PFC06, PFC07, PFC08, PFC09, PFC10

NAME: L-CYSTINE FREE

PERFORMANCE CERTIFIED

SECTION 2. COMPOSITION/INFORMATION ON INGREDIENT

SUBSTANCE NAME

CAS #

SARA

L-CYSTINE

56-89-3

FORMULA: C6H12N2O4S2

SYNONYMS L-ALANINE, 3,3’-DITHIOBIS- *

BIS(BETA-AMINO-BETA-CARBOXYETHYL)DISULFIDE *

CYSTEINE DISULFIDE * L-CYSTEINE DISULFIDE *

CYSTIN * L-CYSTIN * CYSTINE ACID * (-)-CYSTINE *

L-CYSTINE (9CI) * 1-CYSTINE * L-(-)-CYSTINE *

BETA,BETA’-DIAMINO-BETA,BETA’-DICARBOXYDIETHYL

DISULFIDE * DICYSTEINE *

3,3’-DITHIOBIS(2-AMINOPROPANOIC ACID) *

(R-(R*,R*))-3,3’-DITHIOBIS(2-AMINOPROPANOIC ACID)

* BETA,BETA’-DITHIODIALANINE * OXIDIZED

L-CYSTEINE * PROPANOIC ACID,

3,3’-DITHIOBIS(2-AMINO-, (R-(R*,R*))-

RTECS NUMBER: HA2690000

SECTION 3. HAZARDS IDENTIFICATION

HMIS RATING

HEALTH: 0

FLAMMABILITY: 0

REACTIVITY: 0

NFPA RATING

HEALTH: 0

FLAMMABILITY: 0

REACTIVITY: 0

FOR ADDITIONAL INFORMATION ON TOXICITY, PLEASE REFER TO SECTION 11.

SECTION 4. FIRST AID MEASURES

ORAL EXPOSURE

IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS

CONSCIOUS. CALL A PHYSICIAN.

INHALATION EXPOSURE

IF INHALED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT,

CALL A PHYSICIAN.

DERMAL EXPOSURE

IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS

AMOUNTS OF WATER.

EYE EXPOSURE

IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF

WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY

SEPARATING THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

SECTION 5. FIRE FIGHTING MEASURES

FLASH POINT

N/A

AUTOIGNITION TEMP

N/A

FLAMMABILITY

N/A

EXTINGUISHING MEDIA

SUITABLE: WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER, OR

APPROPRIATE FOAM.

FIREFIGHTING

PROTECTIVE EQUIPMENT: WEAR SELF-CONTAINED BREATHING APPARATUS

AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND EYES.

SPECIFIC HAZARD(S): EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. ACCIDENTAL RELEASE MEASURES

PROCEDURE(S) OF PERSONAL PRECAUTION(S)

EXERCISE APPROPRIATE PRECAUTIONS TO MINIMIZE DIRECT CONTACT WITH

SKIN OR EYES AND PREVENT INHALATION OF DUST.

METHODS FOR CLEANING UP

SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID

RAISING DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL

PICKUP IS COMPLETE.

SECTION 7. HANDLING AND STORAGE

HANDLING

USER EXPOSURE: AVOID INHALATION. AVOID CONTACT WITH EYES, SKIN,

AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.

STORAGE

SUITABLE: KEEP TIGHTLY CLOSED.

SECTION 8. EXPOSURE CONTROLS / PPE

ENGINEERING CONTROLS

SAFETY SHOWER AND EYE BATH. MECHANICAL EXHAUST REQUIRED.

PERSONAL PROTECTIVE EQUIPMENT

RESPIRATORY: WEAR DUST MASK.

HAND: PROTECTIVE GLOVES.

EYE: CHEMICAL SAFETY GOGGLES.

GENERAL HYGIENE MEASURES

WASH THOROUGHLY AFTER HANDLING.

SECTION 9. PHYSICAL/CHEMICAL PROPERTIES

APPEARANCE PHYSICAL STATE: SOLID

COLOR: WHITE

FORM: POWDER

PROPERTY VALUE AT TEMPERATURE OR PRESSURE

MOLECULAR WEIGHT 240.3 AMU

PH N/A

BP/BP RANGE N/A

MP/MP RANGE 240 °C

FREEZING POINT N/A

VAPOR PRESSURE N/A

VAPOR DENSITY N/A

SATURATED VAPOR CONC. N/A

SG/DENSITY N/A

BULK DENSITY N/A

ODOR THRESHOLD N/A

VOLATILE% N/A

VOC CONTENT N/A

WATER CONTENT N/A

SOLVENT CONTENT N/A

EVAPORATION RATE N/A

VISCOSITY N/A

SURFACE TENSION N/A

PARTITION COEFFICIENT N/A

DECOMPOSITION TEMP. N/A

FLASH POINT N/A

EXPLOSION LIMITS N/A

FLAMMABILITY N/A

AUTOIGNITION TEMP N/A

REFRACTIVE INDEX N/A

OPTICAL ROTATION DEGREE OF ROTATION: 10 G/L SOLVENT: 1 M HCL

-259 219 (+/-5)

MISCELLANEOUS DATA N/A

SOLUBILITY SOLVENT: 0.2 M IN HCL 1.0 M, 20°C COMPLETE,

COLORLESS

N/A = NOT AVAILABLE

SECTION 10. STABILITY AND REACTIVITY

STABILITY

STABLE: STABLE.

MATERIALS TO AVOID: STRONG OXIDIZING AGENTS.

HAZARDOUS DECOMPOSITION PRODUCTS

HAZARDOUS DECOMPOSITION PRODUCTS: CARBON MONOXIDE, CARBON DIOXIDE,

NITROGEN OXIDES, SULFUR OXIDES.

HAZARDOUS POLYMERIZATION

HAZARDOUS POLYMERIZATION: WILL NOT OCCUR

ROUTE OF EXPOSURE

SKIN CONTACT: MAY CAUSE SKIN IRRITATION.

SKIN ABSORPTION: MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.

EYE CONTACT: MAY CAUSE EYE IRRITATION.

INHALATION: MAY BE HARMFUL IF INHALED. MATERIAL MAY BE

IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT.

INGESTION: MAY BE HARMFUL IF SWALLOWED.

SIGNS AND SYMPTOMS OF EXPOSURE

TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND

TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.

TOXICITY DATA

INTRAPERITONEAL

MOUSE

>961 MG/KG

LD50

SECTION 12. ECOLOGICAL INFORMATION

NO DATA AVAILABLE.

SECTION 13. DISPOSAL CONSIDERATIONS

APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION

CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE

OF THIS MATERIAL. DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE

SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN

AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE, AND LOCAL

ENVIRONMENTAL REGULATIONS.

SECTION 14. TRANSPORT INFORMATION

CONTACT PROFOLDIN FOR TRANSPORTATION INFORMATION.

SECTION 15. REGULATORY INFORMATION

UNITED STATES REGULATORY INFORMATION

SARA LISTED: NO

TSCA INVENTORY ITEM: YES

CANADA REGULATORY INFORMATION

WHMIS CLASSIFICATION: THIS PRODUCT HAS BEEN CLASSIFIED IN

ACCORDANCE WITH THE HAZARD CRITERIA OF THE CPR, AND THE MSDS

CONTAINS ALL THE INFORMATION REQUIRED BY THE CPR.

DSL: YES

NDSL: NO

SECTION 16. OTHER INFORMATION

THIS PRODUCT IS FOR R&D USE ONLY. IT IS NOT FOR DRUG, HOUSEHOLD

OR OTHER USES. EMPLOYERS SHOULD USE THIS INFORMATION ONLY AS A

SUPPLEMENT TO OTHER INFORMATION GATHERED BY THEM, AND SHOULD MAKE

INDEPENDENT JUDGEMENT OF SUITABILITY OF THIS INFORMATION TO ENSURE

PROPER USE AND PROTECT THE HEALTH AND SAFETY OF EMPLOYEES. THIS

INFORMATION IS FURNISHED WITHOUT WARRANTY, AND ANY USE OF THE

PRODUCT NOT IN CONFORMANCE WITH THIS MATERIAL SAFETY DATA SHEET,

OR IN COMBINATION WITH ANY OTHER PRODUCT OR PROCESS, IS THE

RESPONSIBILITY OF THE USER. THE ABOVE INFORMATION IS BELIEVED

TO BE CORRECT BUT DOES NOT PURPORT TO BE ALL INCLUSIVE AND SHALL

BE USED ONLY AS A GUIDE. PROFOLDIN SHALL NOT BE HELD LIABLE FOR

ANY DAMAG RESULTING FROM HANDLING OR FROM CONTACT WITH THE ABOVE

PRODUCT.

SECTION 1. CHEMICAL IDENTIFICATION

CATALOG #: SFC01-10, SFC01, SFC02, SFC03, SFC04, SFC05, SFC06, SFC07, SFC08, SFC09, SFC10

PFC01, PFC02, PFC03, PFC04, PFC05, PFC06, PFC07, PFC08, PFC09, PFC10

NAME: L-CYSTEINE

SECTION 2. COMPOSITION/INFORMATION ON INGREDIENT

SUBSTANCE NAME

CAS #

SARA

L(+)-CYSTEINE

52-90-4

FORMULA: C3H7NO2S

SYNONYMS L-ALANINE, 3-MERCAPTO- *

2-AMINO-3-MERCAPTOPROPIONIC ACID * CYSTEIN *

CYSTEINE * L-CYSTEINE (9CI) * L-(+)-CYSTEINE *

HALF-CYSTEINE * BETA-MERCAPTOALANINE * NSC-8746 *

THIOSERINE

RTECS NUMBER: HA1600000

SECTION 3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW

HARMFUL.

HARMFUL IF SWALLOWED.

HMIS RATING

HEALTH: 1

FLAMMABILITY: 0

REACTIVITY: 0

NFPA RATING

HEALTH: 1

FLAMMABILITY: 0

REACTIVITY: 0

FOR ADDITIONAL INFORMATION ON TOXICITY, PLEASE REFER TO SECTION 11.

SECTION 4. FIRST AID MEASURES

ORAL EXPOSURE

IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS

CONSCIOUS. CALL A PHYSICIAN.

INHALATION EXPOSURE

IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE

ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.

DERMAL EXPOSURE

IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER FOR

AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES.

CALL A PHYSICIAN.

EYE EXPOSURE

IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF

WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY

SEPARATING THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

SECTION 5. FIRE FIGHTING MEASURES

FLASH POINT

N/A

AUTOIGNITION TEMP

N/A

FLAMMABILITY

N/A

EXTINGUISHING MEDIA

SUITABLE: WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER, OR

APPROPRIATE FOAM.

FIREFIGHTING

PROTECTIVE EQUIPMENT: WEAR SELF-CONTAINED BREATHING APPARATUS

AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND EYES.

SPECIFIC HAZARD(S): EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. ACCIDENTAL RELEASE MEASURES

PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL

EVACUATE AREA.

PROCEDURE(S) OF PERSONAL PRECAUTION(S)

WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS, AND HEAVY

RUBBER GLOVES.

METHODS FOR CLEANING UP

SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID

RAISING DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL

PICKUP IS COMPLETE.

SECTION 7. HANDLING AND STORAGE

HANDLING

USER EXPOSURE: DO NOT BREATHE DUST. AVOID CONTACT WITH EYES,

SKIN, AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.

STORAGE

SUITABLE: KEEP TIGHTLY CLOSED.

SECTION 8. EXPOSURE CONTROLS / PPE

ENGINEERING CONTROLS

SAFETY SHOWER AND EYE BATH. MECHANICAL EXHAUST REQUIRED.

PERSONAL PROTECTIVE EQUIPMENT

RESPIRATORY: GOVERNMENT APPROVED RESPIRATOR.

HAND: COMPATIBLE CHEMICAL-RESISTANT GLOVES.

EYE: CHEMICAL SAFETY GOGGLES.

GENERAL HYGIENE MEASURES

WASH THOROUGHLY AFTER HANDLING.

SECTION 9. PHYSICAL/CHEMICAL PROPERTIES

APPEARANCE PHYSICAL STATE: SOLID

COLOR: COLORLESS

FORM: FINE CRYSTALS

PROPERTY VALUE AT TEMPERATURE OR PRESSURE

MOLECULAR WEIGHT 121.16 AMU

PH N/A

BP/BP RANGE N/A

MP/MP RANGE 220 °C

FREEZING POINT N/A

VAPOR PRESSURE N/A

VAPOR DENSITY N/A

SATURATED VAPOR CONC. N/A

SG/DENSITY N/A

BULK DENSITY N/A

ODOR THRESHOLD N/A

VOLATILE% N/A

VOC CONTENT N/A

WATER CONTENT N/A

SOLVENT CONTENT N/A

EVAPORATION RATE N/A

VISCOSITY N/A

SURFACE TENSION N/A

PARTITION COEFFICIENT N/A

DECOMPOSITION TEMP. N/A

FLASH POINT N/A

EXPLOSION LIMITS N/A

FLAMMABILITY N/A

AUTOIGNITION TEMP N/A

REFRACTIVE INDEX N/A

OPTICAL ROTATION DEGREE OF ROTATION: 50 G/L SOLVENT: 5 M HCL

+9.8 - +7.6 (+/-0.5)

MISCELLANEOUS DATA N/A

SOLUBILITY SOLVENT: 1 M IN HCL 1 M, 20°C COMPLETE,

COLORLESS

N/A = NOT AVAILABLE

SECTION 10. STABILITY AND REACTIVITY

STABILITY

STABLE: STABLE.

MATERIALS TO AVOID: STRONG OXIDIZING AGENTS.

HAZARDOUS DECOMPOSITION PRODUCTS

HAZARDOUS DECOMPOSITION PRODUCTS: CARBON MONOXIDE, CARBON DIOXIDE,

NITROGEN OXIDES, SULFUR OXIDES.

HAZARDOUS POLYMERIZATION

HAZARDOUS POLYMERIZATION: WILL NOT OCCUR

SECTION 11. TOXICOLOGICAL INFORMATION

ROUTE OF EXPOSURE

SKIN CONTACT: MAY CAUSE SKIN IRRITATION.

SKIN ABSORPTION: MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.

EYE CONTACT: MAY CAUSE EYE IRRITATION.

INHALATION: MAY BE HARMFUL IF INHALED. MATERIAL MAY BE

IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT.

INGESTION: HARMFUL IF SWALLOWED.

SIGNS AND SYMPTOMS OF EXPOSURE

TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND

TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.

TOXICITY DATA

ORAL

RAT

1890 MG/KG

LD50

REMARKS: BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY).

LUNGS, THORAX, OR RESPIRATION: DYSPNEA. KIDNEY, URETER,

BLADDER: OTHER CHANGES IN URINE COMPOSITION.

INTRAPERITONEAL

RAT

1620 MG/KG

LD50

REMARKS: BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY).

BEHAVIORAL: ATAXIA. LUNGS, THORAX, OR RESPIRATION: RESPIRATORY

DEPRESSION.

SUBCUTANEOUS

RAT

1550 MG/KG

LD50

REMARKS: BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY).

BEHAVIORAL: ATAXIA. LUNGS, THORAX, OR RESPIRATION: RESPIRATORY

DEPRESSION.

INTRAVENOUS

RAT

1140 MG/KG

LD50

ORAL

MOUSE

660 MG/KG

LD50

INTRAPERITONEAL

MOUSE

1400 MG/KG

LD50

REMARKS: BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY).

BEHAVIORAL: ATAXIA. LUNGS, THORAX, OR RESPIRATION: RESPIRATORY

DEPRESSION.

SUBCUTANEOUS

MOUSE

1360 MG/KG

LD50

REMARKS: BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY).

BEHAVIORAL: ATAXIA. LUNGS, THORAX, OR RESPIRATION: RESPIRATORY

DEPRESSION.

INTRAVENOUS

MOUSE

1250 MG/KG

LD50

CHRONIC EXPOSURE - MUTAGEN

SPECIES: HUMAN

DOSE: 1 MMOL/L

CELL TYPE: FIBROBLAST

MUTATION TEST: UNSCHEDULED DNA SYNTHESIS

SPECIES: HUMAN

DOSE: 10 MG/L

CELL TYPE: LYMPHOCYTE

MUTATION TEST: SISTER CHROMATID EXCHANGE

SPECIES: RAT

DOSE: 1 MMOL/L

CELL TYPE: LIVER

MUTATION TEST: DNA INHIBITION

SPECIES: HAMSTER

DOSE: 1 MMOL/L

CELL TYPE: OVARY

MUTATION TEST: CYTOGENETIC ANALYSIS

SPECIES: HAMSTER

DOSE: 100 UMOL/L

CELL TYPE: OVARY

MUTATION TEST: SISTER CHROMATID EXCHANGE

CHRONIC EXPOSURE - REPRODUCTIVE HAZARD

SPECIES: RAT

DOSE: 100 MG/KG

ROUTE OF APPLICATION: INTRAPERITONEAL

EXPOSURE TIME: (12D PREG)

RESULT: EFFECTS ON FERTILITY: LITTER SIZE (E.G.; # FETUSES PER

LITTER; MEASURED BEFORE BIRTH).

SPECIES: MOUSE

DOSE: 3600 MG/KG

ROUTE OF APPLICATION: ORAL

EXPOSURE TIME: (7-12D PREG)

RESULT: EFFECTS ON NEWBORN: PHYSICAL.

SPECIES: MOUSE

DOSE: 27600 MG/KG

ROUTE OF APPLICATION: ORAL

EXPOSURE TIME: (23D PRE)

RESULT: MATERNAL EFFECTS: MENSTRUAL CYCLE CHANGES OR DISORDERS.

SPECIES: MOUSE

DOSE: 6 GM/KG

ROUTE OF APPLICATION: ORAL

EXPOSURE TIME: (30D MALE)

RESULT: PATERNAL EFFECTS: PROSTATE, SEMINAL VESSICLE, COWPER’S

GLAND, ACCESSORY GLANDS.

SECTION 12. ECOLOGICAL INFORMATION

NO DATA AVAILABLE.

SECTION 13. DISPOSAL CONSIDERATIONS

APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION

CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE

OF THIS MATERIAL. DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE

SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN

AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE, AND LOCAL

ENVIRONMENTAL REGULATIONS.

SECTION 14. TRANSPORT INFORMATION

CONTACT PROFOLDIN FOR TRANSPORTATION INFORMATION.

SECTION 15. REGULATORY INFORMATION

EU ADDITIONAL CLASSIFICATION

SYMBOL OF DANGER: XN

INDICATION OF DANGER: HARMFUL.

R: 22

RISK STATEMENTS: HARMFUL IF SWALLOWED.

US CLASSIFICATION AND LABEL TEXT

INDICATION OF DANGER: HARMFUL.

RISK STATEMENTS: HARMFUL IF SWALLOWED.

UNITED STATES REGULATORY INFORMATION

SARA LISTED: NO

TSCA INVENTORY ITEM: YES

CANADA REGULATORY INFORMATION

WHMIS CLASSIFICATION: THIS PRODUCT HAS BEEN CLASSIFIED IN

ACCORDANCE WITH THE HAZARD CRITERIA OF THE CPR, AND THE MSDS

CONTAINS ALL THE INFORMATION REQUIRED BY THE CPR.

DSL: YES

NDSL: NO

SECTION 16. OTHER INFORMATION

THIS PRODUCT IS FOR R&D USE ONLY. IT IS NOT FOR DRUG, HOUSEHOLD

OR OTHER USES. EMPLOYERS SHOULD USE THIS INFORMATION ONLY AS A

SUPPLEMENT TO OTHER INFORMATION GATHERED BY THEM, AND SHOULD MAKE

INDEPENDENT JUDGEMENT OF SUITABILITY OF THIS INFORMATION TO ENSURE

PROPER USE AND PROTECT THE HEALTH AND SAFETY OF EMPLOYEES. THIS

INFORMATION IS FURNISHED WITHOUT WARRANTY, AND ANY USE OF THE

PRODUCT NOT IN CONFORMANCE WITH THIS MATERIAL SAFETY DATA SHEET,

OR IN COMBINATION WITH ANY OTHER PRODUCT OR PROCESS, IS THE

RESPONSIBILITY OF THE USER. THE ABOVE INFORMATION IS BELIEVED

TO BE CORRECT BUT DOES NOT PURPORT TO BE ALL INCLUSIVE AND SHALL

BE USED ONLY AS A GUIDE. PROFOLDIN SHALL NOT BE HELD LIABLE FOR

ANY DAMAG RESULTING FROM HANDLING OR FROM CONTACT WITH THE ABOVE

PRODUCT.

SECTION 1. CHEMICAL IDENTIFICATION

CATALOG #: SFC01-10, SFC01, SFC02, SFC03, SFC04, SFC05, SFC06, SFC07, SFC08, SFC09, SFC10

PFC01, PFC02, PFC03, PFC04, PFC05, PFC06, PFC07, PFC08, PFC09, PFC10

NAME: POLYOXYETHYLENE 23 LAURYL ETHER

SECTION 2. COMPOSITION/INFORMATION ON INGREDIENT

SUBSTANCE NAME

CAS #

SARA

POLYOXYETHYLENE LAURYL ETHER

9002-92-0

FORMULA: (C2H4O)NC12H26O

SYNONYMS ALDOSPERSE L 9 * ASK-010 * ATLAS G-2133 * ATLAS

G-3705 * BASE LP 12 * BL 9 * BL 9EX * BRIJ 23 *

BRIJ 30 * BRIJ 35 * BRIJ 30SP * CHIMIPAL AE 3 *

CIMAGEL * DEHYDOL LS 4 * DEPEG * DO 9 *

DODECANOL, ETHOXYLATE * DODECANOL-ETHYLENE OXIDE

(9.5 MOLES) CONDENSATE * DODECANOL,

POLYETHOXYLATED * DODECYL ALCOHOL, ETHOXYLATED *

ALPHA-DODECYL-OMEGA-HYDROXY-POLYOXYETHYLENE *

DODECYL-POLYAETHYLENOXYD-AETHER (GERMAN) *

DODECYL POLY(OXYETHYLENE)ETHER * DU PONT WK *

EMAL 108 * EMALEX 715 * EMULGEN 100 * EMULGEN 105

* EMULGEN 108 * EMULGEN 109 * EMULGEN 120 *

EMULGEN 147 * EMULMIN L 500 * ETHAL LA-X *

ETHOSPERSE LA-4 * ETHOSPERSE LA 12 * ETHOSPERSE

LA 23 * ETHOXYLATED LAURYL ALCOHOL * G 3707 * G

3711 * G-2130A * HYDROXYPOLYETHOXYDODECANE * LA 7

* LA (ALCOHOL) * LANETTES * LAURETH * LAURETH 9 *

LAURETH 12 * LAURETH 23 * LAUROMACROGOL *

LAUROMACROGOL 400 * LAURYL ALCOHOL, ETHOXYLATED *

LAURYL POLYETHYLENE GLYCOL ETHER * LAURYL

POLY(OXYETHYLENE) ETHER * LIPAL 4LA * LIPOCOL L-4

* LIPOCOL L 12 * LIPOCOL L-23 * LUBROL 12A9 *

LUBROL PX * MARLIPAL 1217 * MERGITAL LM 11 *

NCI-C54875 * NEWCOL 1203 * NIKKOL BL * NIKKOL BL

SECTION 3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW

HARMFUL.

HARMFUL IF SWALLOWED. IRRITATING TO SKIN. RISK OF SERIOUS DAMAGE

TO EYES.

HMIS RATING

HEALTH: 2

FLAMMABILITY: 0

REACTIVITY: 0

NFPA RATING

HEALTH: 2

FLAMMABILITY: 0

REACTIVITY: 0

FOR ADDITIONAL INFORMATION ON TOXICITY, PLEASE REFER TO SECTION 11.

SECTION 4. FIRST AID MEASURES

ORAL EXPOSURE

IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS

CONSCIOUS. CALL A PHYSICIAN.

INHALATION EXPOSURE

IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE

ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.

DERMAL EXPOSURE

IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS

AMOUNTS OF WATER.

EYE EXPOSURE

IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS

OF WATER FOR AT LEAST 15 MINUTES.

SECTION 5. FIRE FIGHTING MEASURES

FLASH POINT

235 °F 113 °C METHOD: CLOSED CUP

AUTOIGNITION TEMP

N/A

FLAMMABILITY

N/A

EXTINGUISHING MEDIA

SUITABLE: WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER, OR

APPROPRIATE FOAM.

FIREFIGHTING

PROTECTIVE EQUIPMENT: WEAR SELF-CONTAINED BREATHING APPARATUS

AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND EYES.

SPECIFIC HAZARD(S): EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. ACCIDENTAL RELEASE MEASURES

PROCEDURE(S) OF PERSONAL PRECAUTION(S)

WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS, AND

HEAVY RUBBER GLOVES.

METHODS FOR CLEANING UP

ABSORB ON SAND OR VERMICULITE AND PLACE IN CLOSED CONTAINERS FOR

DISPOSAL. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL

PICKUP IS COMPLETE.

SECTION 7. HANDLING AND STORAGE

HANDLING

USER EXPOSURE: DO NOT BREATHE VAPOR. AVOID CONTACT WITH EYES,

SKIN, AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.

STORAGE

SUITABLE: KEEP TIGHTLY CLOSED.

SECTION 8. EXPOSURE CONTROLS / PPE

ENGINEERING CONTROLS

MECHANICAL EXHAUST REQUIRED. SAFETY SHOWER AND EYE BATH.

PERSONAL PROTECTIVE EQUIPMENT

RESPIRATORY: GOVERNMENT APPROVED RESPIRATOR.

HAND: COMPATIBLE CHEMICAL-RESISTANT GLOVES.

EYE: CHEMICAL SAFETY GOGGLES.

GENERAL HYGIENE MEASURES

WASH THOROUGHLY AFTER HANDLING.

SECTION 9. PHYSICAL/CHEMICAL PROPERTIES

APPEARANCE PHYSICAL STATE: SEMI-SOLID MELTING TO A

CLEAR COLORLESS LIQUID

PROPERTY VALUE AT TEMPERATURE OR PRESSURE

MOLECULAR WEIGHT N/A

PH 5.5 - 7.5 CONCENTRATION: 100 G/L

BP/BP RANGE 100 °C 760 MMHG

MP/MP RANGE 41 - 45 °C

FREEZING POINT N/A

VAPOR PRESSURE < 1 MMHG 20 °C

VAPOR DENSITY N/A

SATURATED VAPOR CONC. N/A

SG/DENSITY N/A

BULK DENSITY N/A

ODOR THRESHOLD N/A

VOLATILE% N/A

VOC CONTENT N/A

WATER CONTENT N/A

SOLVENT CONTENT N/A

EVAPORATION RATE N/A

VISCOSITY N/A

SURFACE TENSION N/A

PARTITION COEFFICIENT N/A

DECOMPOSITION TEMP. N/A

FLASH POINT 235 °F 113 °C METHOD: CLOSED CUP

EXPLOSION LIMITS N/A

FLAMMABILITY N/A

AUTOIGNITION TEMP N/A

REFRACTIVE INDEX N/A

OPTICAL ROTATION N/A

MISCELLANEOUS DATA N/A

SOLUBILITY SOLUBILITY IN WATER: SOLUBLE.

N/A = NOT AVAILABLE

SECTION 10. STABILITY AND REACTIVITY

STABILITY

STABLE: STABLE.

MATERIALS TO AVOID: STRONG OXIDIZING AGENTS.

HAZARDOUS DECOMPOSITION PRODUCTS

HAZARDOUS DECOMPOSITION PRODUCTS: NATURE OF DECOMPOSITION PRODUCTS

NOT KNOWN.

HAZARDOUS POLYMERIZATION

HAZARDOUS POLYMERIZATION: WILL NOT OCCUR

SECTION 11. TOXICOLOGICAL INFORMATION

ROUTE OF EXPOSURE

SKIN CONTACT: CAUSES SKIN IRRITATION.

SKIN ABSORPTION: MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.

EYE CONTACT: CAUSES SEVERE EYE IRRITATION.

INHALATION: MAY BE HARMFUL IF INHALED. MATERIAL MAY BE

IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT.

INGESTION: HARMFUL IF SWALLOWED.

SIGNS AND SYMPTOMS OF EXPOSURE

TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND

TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.

TOXICITY DATA

ORAL

RAT

1000 MG/KG

LD50

REMARKS: GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH.

GASTROINTESTINAL: OTHER CHANGES. LIVER: FATTY LIVER DEGENERATION.

INTRAPERITONEAL

RAT

125 MG/KG

LD50

REMARKS: GASTROINTESTINAL: OTHER CHANGES.

SUBCUTANEOUS

RAT

953 MG/KG

LD50

INTRAVENOUS

RAT

27 MG/KG

LD50

ORAL

MOUSE

1170 MG/KG

LD50

REMARKS: PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS

WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE).

BEHAVIORAL: CHANGE IN MOTOR ACTIVITY (SPECIFIC ASSAY). LUNGS,

THORAX, OR RESPIRATION: OTHER CHANGES.

INTRAPERITONEAL

MOUSE

160 MG/KG

LD50

SUBCUTANEOUS

MOUSE

792300 UG/KG

LD50

INTRAVENOUS

MOUSE

100 MG/KG

LD50

INTRAVENOUS

RABBIT

36 MG/KG

LD50

REMARKS: BEHAVIORAL: CHANGE IN MOTOR ACTIVITY (SPECIFIC ASSAY).

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES. KIDNEY, URETER,

BLADDER: HEMATURIA.

PARENTERAL

RABBIT

>75 MG/KG

LD50

INTRATRACHEAL

RABBIT

>15 MG/KG

LD50

ORAL

GUINEA PIG

384 MG/KG

LD50

REMARKS: PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS

WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE).

BEHAVIORAL: CHANGE IN MOTOR ACTIVITY (SPECIFIC ASSAY). LUNGS,

THORAX, OR RESPIRATION: OTHER CHANGES.

INTRAVENOUS

GUINEA PIG

38 MG/KG

LD50

REMARKS: BEHAVIORAL: CHANGE IN MOTOR ACTIVITY (SPECIFIC ASSAY).

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES. KIDNEY, URETER,

BLADDER: HEMATURIA.

IRRITATION DATA

SKIN

HUMAN

6 MG

REMARKS: MODERATE IRRITATION EFFECT

SKIN

RABBIT

500 MG

24H

REMARKS: MILD IRRITATION EFFECT

SKIN

RABBIT

75 MG

24H

REMARKS: MILD IRRITATION EFFECT

SKIN

RABBIT

500 MG

24H

REMARKS: MODERATE IRRITATION EFFECT

EYES

RABBIT

100 MG

EYES

RABBIT

0.75 MG

24H

REMARKS: SEVERE IRRITATION EFFECT

SECTION 12. ECOLOGICAL INFORMATION

ACUTE ECOTOXICITY TESTS

TEST TYPE: EC50 ALGAE

SPECIES: SELENASTRUM CAPRICORNUTUM RESP.

VALUE: 2 - 4 MG/L

TEST TYPE: EC50 DAPHNIA

SPECIES: DAPHNIA MAGNA

TIME: 48 H

VALUE: 4.78 - 7.580 MG/L

TEST TYPE: LC50 FISH

SPECIES: CYPRINUS CARPIO

TIME: 96 H

VALUE: 1.4 MG/L

TEST TYPE: LC50 FISH

SPECIES: OTHER FISH

TIME: 96 H

VALUE: 1.5 MG/L

SECTION 13. DISPOSAL CONSIDERATIONS

APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION

CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE

OF THIS MATERIAL. DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE

SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN

AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE, AND LOCAL

ENVIRONMENTAL REGULATIONS.

SECTION 14. TRANSPORT INFORMATION

CONTACT PROFOLDIN FOR TRANSPORTATION INFORMATION.

SECTION 15. REGULATORY INFORMATION

EU ADDITIONAL CLASSIFICATION

SYMBOL OF DANGER: XN

INDICATION OF DANGER: HARMFUL.

R: 22 38 41

RISK STATEMENTS: HARMFUL IF SWALLOWED. IRRITATING TO SKIN. RISK

OF SERIOUS DAMAGE TO EYES.

S: 26 36/37/39

SAFETY STATEMENTS: IN CASE OF CONTACT WITH EYES, RINSE

IMMEDIATELY WITH PLENTY OF WATER AND SEEK MEDICAL ADVICE. WEAR

SUITABLE PROTECTIVE CLOTHING, GLOVES, AND EYE/FACE PROTECTION.

US CLASSIFICATION AND LABEL TEXT

INDICATION OF DANGER: HARMFUL.

RISK STATEMENTS: HARMFUL IF SWALLOWED. IRRITATING TO SKIN. RISK

OF SERIOUS DAMAGE TO EYES.

SAFETY STATEMENTS: IN CASE OF CONTACT WITH EYES, RINSE

IMMEDIATELY WITH PLENTY OF WATER AND SEEK MEDICAL ADVICE. WEAR

SUITABLE PROTECTIVE CLOTHING, GLOVES, AND EYE/FACE PROTECTION.

UNITED STATES REGULATORY INFORMATION

SARA LISTED: NO

TSCA INVENTORY ITEM: YES

CANADA REGULATORY INFORMATION

WHMIS CLASSIFICATION: THIS PRODUCT HAS BEEN CLASSIFIED IN

ACCORDANCE WITH THE HAZARD CRITERIA OF THE CPR, AND THE MSDS

CONTAINS ALL THE INFORMATION REQUIRED BY THE CPR.

DSL: YES

NDSL: NO

SECTION 16. OTHER INFORMATION

THIS PRODUCT IS FOR R&D USE ONLY. IT IS NOT FOR DRUG, HOUSEHOLD

OR OTHER USES. EMPLOYERS SHOULD USE THIS INFORMATION ONLY AS A

SUPPLEMENT TO OTHER INFORMATION GATHERED BY THEM, AND SHOULD MAKE

INDEPENDENT JUDGEMENT OF SUITABILITY OF THIS INFORMATION TO ENSURE

PROPER USE AND PROTECT THE HEALTH AND SAFETY OF EMPLOYEES. THIS

INFORMATION IS FURNISHED WITHOUT WARRANTY, AND ANY USE OF THE

PRODUCT NOT IN CONFORMANCE WITH THIS MATERIAL SAFETY DATA SHEET,

OR IN COMBINATION WITH ANY OTHER PRODUCT OR PROCESS, IS THE

RESPONSIBILITY OF THE USER. THE ABOVE INFORMATION IS BELIEVED

TO BE CORRECT BUT DOES NOT PURPORT TO BE ALL INCLUSIVE AND SHALL

BE USED ONLY AS A GUIDE. PROFOLDIN SHALL NOT BE HELD LIABLE FOR

ANY DAMAG RESULTING FROM HANDLING OR FROM CONTACT WITH THE ABOVE

PRODUCT.

SECTION 1. CHEMICAL IDENTIFICATION

CATALOG #: SFC01-10, SFC01, SFC02, SFC03, SFC04, SFC05, SFC06, SFC07, SFC08, SFC09, SFC10

PFC01, PFC02, PFC03, PFC04, PFC05, PFC06, PFC07, PFC08, PFC09, PFC10

NAME: B-CYCLODEXTRIN

SECTION 2. COMPOSITION/INFORMATION ON INGREDIENT

SUBSTANCE NAME

CAS #

SARA

B-CYCLODEXTRIN

7585-39-9

FORMULA: C42H70O35

SYNONYMS BETA-CYCLOAMYLOSE * CYCLOHEPTAAMYLOSE *

BETA-CYCLOHEPTAAMYLOSE * CYCLOHEPTAGLUCAN *

CYCLOHEPTAGLUCOSAN * CYCLOMALTOHEPTAOSE *

BETA-DEXTRIN * SCHARDINGER BETA-DEXTRIN

RTECS NUMBER: GU2293000

SECTION 3. HAZARDS IDENTIFICATION

HMIS RATING

HEALTH: 0

FLAMMABILITY: 0

REACTIVITY: 0

NFPA RATING

HEALTH: 0

FLAMMABILITY: 0

REACTIVITY: 0

FOR ADDITIONAL INFORMATION ON TOXICITY, PLEASE REFER TO SECTION 11.

SECTION 4. FIRST AID MEASURES

ORAL EXPOSURE

IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS

CONSCIOUS. CALL A PHYSICIAN.

INHALATION EXPOSURE

IF INHALED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT,

CALL A PHYSICIAN.

DERMAL EXPOSURE

IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS

AMOUNTS OF WATER.

EYE EXPOSURE

IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF

WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY

SEPARATING THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

SECTION 5. FIRE FIGHTING MEASURES

FLASH POINT

N/A

AUTOIGNITION TEMP

N/A

FLAMMABILITY

N/A

EXTINGUISHING MEDIA

SUITABLE: WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER, OR

APPROPRIATE FOAM.

FIREFIGHTING

PROTECTIVE EQUIPMENT: WEAR SELF-CONTAINED BREATHING APPARATUS

AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND EYES.

SPECIFIC HAZARD(S): EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. ACCIDENTAL RELEASE MEASURES

PROCEDURE(S) OF PERSONAL PRECAUTION(S)

EXERCISE APPROPRIATE PRECAUTIONS TO MINIMIZE DIRECT CONTACT WITH

SKIN OR EYES AND PREVENT INHALATION OF DUST.

METHODS FOR CLEANING UP

SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID

RAISING DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL

PICKUP IS COMPLETE.

SECTION 7. HANDLING AND STORAGE

HANDLING

USER EXPOSURE: AVOID INHALATION. AVOID CONTACT WITH EYES, SKIN,

AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.

STORAGE

SUITABLE: KEEP TIGHTLY CLOSED.

SECTION 8. EXPOSURE CONTROLS / PPE

ENGINEERING CONTROLS

SAFETY SHOWER AND EYE BATH. MECHANICAL EXHAUST REQUIRED.

PERSONAL PROTECTIVE EQUIPMENT

RESPIRATORY: WEAR DUST MASK.

HAND: PROTECTIVE GLOVES.

EYE: CHEMICAL SAFETY GOGGLES.

GENERAL HYGIENE MEASURES

WASH THOROUGHLY AFTER HANDLING.

SECTION 9. PHYSICAL/CHEMICAL PROPERTIES

APPEARANCE COLOR: WHITE

FORM: POWDER

PROPERTY VALUE AT TEMPERATURE OR PRESSURE

MOLECULAR WEIGHT 1,135.01 AMU

PH N/A

BP/BP RANGE N/A

MP/MP RANGE 290 °C

FREEZING POINT N/A

VAPOR PRESSURE N/A

VAPOR DENSITY N/A

SATURATED VAPOR CONC. N/A

SG/DENSITY N/A

BULK DENSITY N/A

ODOR THRESHOLD N/A

VOLATILE% N/A

VOC CONTENT N/A

WATER CONTENT 10 - 13 %

SOLVENT CONTENT N/A

EVAPORATION RATE N/A

VISCOSITY N/A

SURFACE TENSION N/A

PARTITION COEFFICIENT N/A

DECOMPOSITION TEMP. N/A

FLASH POINT N/A

EXPLOSION LIMITS N/A

FLAMMABILITY N/A

AUTOIGNITION TEMP N/A

REFRACTIVE INDEX N/A

OPTICAL ROTATION DEGREE OF ROTATION: 15 G/L SOLVENT: H2O

+192 - +162 (+/-3)

MISCELLANEOUS DATA N/A

SOLUBILITY N/A

N/A = NOT AVAILABLE

SECTION 10. STABILITY AND REACTIVITY

STABILITY

STABLE: STABLE.

MATERIALS TO AVOID: STRONG OXIDIZING AGENTS.

HAZARDOUS DECOMPOSITION PRODUCTS

HAZARDOUS DECOMPOSITION PRODUCTS: CARBON MONOXIDE, CARBON DIOXIDE.

HAZARDOUS POLYMERIZATION

HAZARDOUS POLYMERIZATION: WILL NOT OCCUR

SECTION 11. TOXICOLOGICAL INFORMATION

ROUTE OF EXPOSURE

SKIN CONTACT: MAY CAUSE SKIN IRRITATION.

SKIN ABSORPTION: MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.

EYE CONTACT: MAY CAUSE EYE IRRITATION.

INHALATION: MAY BE HARMFUL IF INHALED. MATERIAL MAY BE

IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT.

INGESTION: MAY BE HARMFUL IF SWALLOWED.

SIGNS AND SYMPTOMS OF EXPOSURE

TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND

TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.

TOXICITY DATA

ORAL

RAT

18800 MG/KG

LD50

INTRAPERITONEAL

RAT

356 MG/KG

LD50

SUBCUTANEOUS

RAT

3700 MG/KG

LD50

INTRAVENOUS

RAT

1008 MG/KG

LD50

ORAL

MOUSE

> 12500 MG/KG

LD50

INTRAPERITONEAL

MOUSE

330 MG/KG

LD50

SUBCUTANEOUS

MOUSE

412 MG/KG

LD50

CHRONIC EXPOSURE - REPRODUCTIVE HAZARD

SPECIES: RAT