Penicillin Drug Stability
Penicillin drugs such as Penicillin G and Penicillin V can be hydrolyzed to form penicilloic acid during storage or transportation due to various reasons including the following: (1) the temperature is too high; (2) the solution pH is not optimal for stabilization; or (3) the sample contains lactamase. The hydrolyzed penicillin drug molecule is thermodynamically more stable than the non-hydrolyzed one but completely inactive.
Penicillin Drug Stability Test Kit (Catalog number PST100)
The Penicillin Drug Stability Test Kit (Catalog number PST100) provides a reagent that quickly detects the hydrolyzed form of penicillin drugs including the commonly used Penicillin G and Penicillin V. The reagent, Dye PST, interacts with alpha-amino acids which are the hydrolysis products of penicillin drugs and generates fluorescence at 535 nm with excitation wavelength at 485 nm. The background signal with the non-hydrolyzed penicillin drugs is very low.
The kit can be used to detect hydrolysis of penicillin drugs. It can also be used to detect the lactamase activity using penicillin as a substrate.